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Titolo:
Deficiency of the expression of CD45RA isoform of CD45 common leukocyte antigen in CD4+T lymphocytes in children with infantile cholestasis
Autore:
Socha, P; Michalkiewicz, J; Stachowski, J; Pawlowska, J; Jankowska, I; Barth, C; Socha, J; Madalinski, K;
Indirizzi:
Univ Hosp Cologne, Dept Nephrol, D-50924 Cologne, Germany Univ Hosp Cologne Cologne Germany D-50924 hrol, D-50924 Cologne, Germany Poznan Tech Univ, Sch Med Sci, Inst Pediat, Clin Childrens Dis, PL-60572 Poznan, Poland Poznan Tech Univ Poznan Poland PL-60572 ens Dis, PL-60572 Poznan, Poland
Titolo Testata:
IMMUNOLOGY LETTERS
fascicolo: 3, volume: 75, anno: 2001,
pagine: 179 - 184
SICI:
0165-2478(20010115)75:3<179:DOTEOC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMORY T-CELLS; EXTRAHEPATIC BILIARY ATRESIA; AGE-RELATED-CHANGES; HELPER-INDUCER; MONOCLONAL-ANTIBODY; 2H4 MOLECULE; ACTIVATION; SUBSETS; NAIVE; UCHL1;
Keywords:
CD45 isoforms; infantile cholestasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Stachowski, J Poznan Tech Univ, Sch Med Sci, Pediat Clin, Dial Unit, Szpitalna 27-33, PL-60372 Poznan, Poland Poznan Tech Univ Szpitalna 27-33 Poznan Poland PL-60372 and
Citazione:
P. Socha et al., "Deficiency of the expression of CD45RA isoform of CD45 common leukocyte antigen in CD4+T lymphocytes in children with infantile cholestasis", IMMUNOL LET, 75(3), 2001, pp. 179-184

Abstract

The immunological background of the pathological changes that appear in infantile cholestasis (infections, inflammatory process in the liver) is largely unknown. With the use of double color flow cytometry, we assessed the distribution of functionally different lymphocyte subpopulations in the peripheral blood of 29 infants with extra and intra-hepatic cholestasis (12 and17 patients, respectively), aged from 1 to 8.6 months. Control group consisted of 15 age-matched, healthy infants. We examined: (1) the expression ofCD3, CD4, CD8, CD19 lymphocyte surface receptors; and (2) the distributionof lymphocyte subsets with distinctive surface AE characteristics of 'naive' (CD45RA +) and 'memory' (CD45RO +) cells in both CD4 + and CD8 + cell populations. The surface markers expression was evaluated in terms of percentage of positive cells and receptor density. The following changes in the expression of lymphocyte surface markers are described: (1) a decrease in thepercentage of total CD3 +, CD4 + cells but normal percentage of CD8 + cells and elevated proportion of CD19 + B cells; (2) a reduction of the proportion of 'naive' CD4 + lymphocytes but normal percentage of 'naive' CD8 + as well as 'memory' CD4 + and CD8 + cell subsets; (3) a decrease in density ofCD3, CD4 +, CDS receptors, and D45RA isoform in a subset of 'naive' CD4 + cells. We conclude that deficiency of 'naive' CD4 + T cell subset which possess important effector and immunoregulatory functions, and low expression of certain lymphocyte receptors known to be engaged in T cell activation, possibly reflect a defect of cell mediated immunity that may account for viral and bacterial infections, often observed in infants with cholestasis. (C) 2001 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:02:13