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Titolo:
Genetic variation among four Mexican populations (Huichol, Purepecha, Tarahumara, and Mestizo) revealed by two VNTRs and four STRs
Autore:
Rangel-Villalobos, H; Rivas, F; Sandoval, L; Ibarra, B; Garcia-Carvajal, ZY; Cantu, JM; Figuera, LE;
Indirizzi:
Ctr Invest Biomed Occidente, Div Genet, IMSS, Guadalajara, Jalisco, MexicoCtr Invest Biomed Occidente Guadalajara Jalisco Mexico , Jalisco, Mexico Ctr Invest Bimed Occidente, IMSS, Mol Med Div, Guadalajara, Jalisco, Mexico Ctr Invest Bimed Occidente Guadalajara Jalisco Mexico a, Jalisco, Mexico Univ Guadalajara, Human Genet Doctorate Program, Guadalajara 44430, Jalisco, Mexico Univ Guadalajara Guadalajara Jalisco Mexico 44430 44430, Jalisco, Mexico
Titolo Testata:
HUMAN BIOLOGY
fascicolo: 6, volume: 72, anno: 2000,
pagine: 983 - 995
SICI:
0018-7143(200012)72:6<983:GVAFMP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TANDEM REPEAT LOCI; HYPERVARIABLE REGION; ALLELE FREQUENCIES; VARIABLE NUMBER; D1S80; DIVERSITY; POLYMORPHISMS; HUMTH01; CSF1PO; HUMANS;
Keywords:
tandem repeats; DNA polymorphism; Mexico; population genetics; Amerindians;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Rangel-Villalobos, H Ctr Invest Biomed Occidente, Div Genet, IMSS, Apartado Postal 1-3838, Guadalajara, Jalisco, Mexico Ctr Invest Biomed Occidente Apartado Postal 1-3838 Guadalajara Jalisco Mexico
Citazione:
H. Rangel-Villalobos et al., "Genetic variation among four Mexican populations (Huichol, Purepecha, Tarahumara, and Mestizo) revealed by two VNTRs and four STRs", HUMAN BIOL, 72(6), 2000, pp. 983-995

Abstract

Allele distributions of two polymorphisms with variable number of tandem repeats (VNTR), D1S80 and APOB, and four poly morphisms with short tandem repeats (STR), VWA, TH01, CSF1PO, and HPRTB, were analyzed in three Mexican ethnic groups: Huichol, Purepecha, and Tarahumara. Genotype distribution wasin agreement with Hardy-Weinberg expectations for each locus and ethnic group. Heterozygosity (Ei), power of discrimination, and probability of exclusion were estimated. The three groups presented some distinctive genetic features: (I) a diminished genetic diversity (H = 66.8% to 73.4%) and mean number of alleles by locus (5.8 to 6.3) in comparison with Mexican mestizos (H = 78.3%, 10.5 alleles/locus), and (2) uneven allele distributions as evidenced by "distinctive alleles" with high frequencies, especially in the Tarahumara and the Huichol. Genetic relatedness analysis included data from a previously typed mestizo population, the largest and most widely distributed population in Mexico. Allele distribution differentiation was observed among all four groups, except between mestizo and Purepecha (p > 0.05), whichwas interpreted as indicating a larger Spanish component in the Purepecha as a result of gene flow effects. Although intrapopulation inbreeding (F-1S) was not significant, heterozygote deficiency in the total population (F-1T) and divergence among populations (F-ST) were significant (p < 0.05). Genetic distances displayed a closer relationship among mestizos, Purepechas, and Huichols in relation to Tarahumaras. Correlation between the observed generic features and the geographic isolation level points to genetic drift as the main cause of differentiation among these Mexican populations.

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Documento generato il 23/11/20 alle ore 21:39:59