Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Mood stabilizers and ion regulation
Autore:
El-Mallakh, RS; Huff, MO;
Indirizzi:
Univ Louisville, Sch Med, Dept Psychiat & Behav Sci, Mood Disorders Res Program, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Program, Louisville, KY 40292 USA
Titolo Testata:
HARVARD REVIEW OF PSYCHIATRY
fascicolo: 1, volume: 9, anno: 2001,
pagine: 23 - 32
SICI:
1067-3229(200101/02)9:1<23:MSAIR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; MAGNETIC-RESONANCE SPECTROSCOPY; MANIC-DEPRESSIVE ILLNESS; BIPOLAR AFFECTIVE-DISORDER; INDUCED DIABETIC RATS; NEURO-BLASTOMA CELLS; LONG-TERM LITHIUM; NA+-K+-ATPASE; ANTICONVULSANT DRUGS DIPHENYLHYDANTOIN; INTRACELLULAR CALCIUM-CONCENTRATION;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
175
Recensione:
Indirizzi per estratti:
Indirizzo: El-Mallakh, RS Univ Louisville, Sch Med, Dept Psychiat & Behav Sci, Mood Disorders Res Program, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 ille, KY 40292 USA
Citazione:
R.S. El-Mallakh e M.O. Huff, "Mood stabilizers and ion regulation", HARV R PSYC, 9(1), 2001, pp. 23-32

Abstract

Understanding the pathogenesis and pathophysiology of bipolar disorder is a prerequisite for accelerating the development of effective therapeutic agents and interventions. One of the best clues to these processes lies in shared mechanisms of action of mood-stabilizing agents. All effective mood stabilizers share the ability to attenuate the influx and intracellular accumulation of sodium in an activity-dependent manner. When coupled with independent observations of aberrant ion regulation in mania and bipolar depression, this shared characteristic is potentially significant. A unified hypothesis is presented in which lithium. valproic acid, and carbamazepine are suggested to produce antimanic effects by modifying ion flux and intracellular ion concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:36:26