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Titolo:
Redox-modulated pathways in inflammatory skin diseases
Autore:
Fuchs, J; Zollner, TM; Kaufmann, R; Podda, M;
Indirizzi:
JW Goeth Univ, Sch Med, Dept Dermatol, D-63739 Aschaffenburg, Germany JW Goeth Univ Aschaffenburg Germany D-63739 63739 Aschaffenburg, Germany
Titolo Testata:
FREE RADICAL BIOLOGY AND MEDICINE
fascicolo: 4, volume: 30, anno: 2001,
pagine: 337 - 353
SICI:
0891-5849(20010215)30:4<337:RPIISD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; ALLERGIC CONTACT-DERMATITIS; PROTEIN-KINASE-C; HUMAN EPIDERMAL-KERATINOCYTES; CULTURED HUMAN KERATINOCYTES; CD4(+) T-CELLS; AROMATIC HYDROCARBON CARCINOGENESIS;
Keywords:
skin inflammation; redox; reactive oxygen species; free radicals;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
294
Recensione:
Indirizzi per estratti:
Indirizzo: Fuchs, J JW Goeth Univ, Sch Med, Dept Dermatol, Heinsestr 8, D-63739 Aschaffenburg,Germany JW Goeth Univ Heinsestr 8 Aschaffenburg Germany D-63739 ,Germany
Citazione:
J. Fuchs et al., "Redox-modulated pathways in inflammatory skin diseases", FREE RAD B, 30(4), 2001, pp. 337-353

Abstract

Inflammatory skin diseases account for a large proportion of all skin disorders and constitute a major health problem worldwide. Contact dermatitis, atopic dermatitis, and psoriasis represent the most prevalent inflammatory skin disorders and share a common efferent T-lymphocyte mediated response. Oxidative stress and inflammation have recently been linked to cutaneous damage in T-lymphocyte mediated skin diseases, particularly in contact dermatitis. Insights into the pathophysiology responsible for contact dermatitis can be used to better understand the mechanism of other T-lymphocyte mediated inflammatory skin diseases, and may help to develop novel therapeutic approaches. This review focuses on redox sensitive events in the inflammatoryscenario of contact dermatitis, which comprise for example, several kinases, transcription factors, cytokines, adhesion molecules, dendritic cell surface markers, the T-lymphocyte receptor, and the cutaneous lymphocyte-associated antigen (CLA). In vitro and animal studies clearly point to a centralrole of several distinct but interconnected redox-sensitive pathways in the pathogenesis of contact dermatitis. However, clinical evidence that modulation of the skin's redox state can be used therapeutically to modulate theinflammatory response in contact dermatitis is presently not convincing. The rational for this discrepancy seems to be multi-faceted and complex and will be discussed. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:08:38