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Titolo:
The insulin-like growth factor-I system and hormone replacement therapy
Autore:
Cardim, HJP; Lopes, CMC; Giannella-Neto, D; da Fonseca, AM; Pinotti, JA;
Indirizzi:
Hosp Reg Univ Maringa, Maringa, Parana, Brazil Hosp Reg Univ Maringa Maringa Parana Brazil nga, Maringa, Parana, Brazil Univ Sao Paulo, Sch Med, Dept Gynecol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil ch Med, Dept Gynecol, Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Lab Human Nutr & Metab Dis LIM 25 HC, Cellular & Mol Endocrinol Sect, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Mol Endocrinol Sect, Sao Paulo, Brazil
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 2, volume: 75, anno: 2001,
pagine: 282 - 287
SICI:
0015-0282(200102)75:2<282:TIGFSA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR BINDING PROTEIN-1; POSTMENOPAUSAL WOMEN; TRANSDERMAL ESTROGEN; IGF-I; CONJUGATED ESTROGENS; SOMATOMEDIN-C; FACTOR AXIS; RAT; SECRETION; 17-BETA-ESTRADIOL;
Keywords:
insulin-like growth factor; insulin-like growth factor binding proteins; menopause; estrogens; progestagens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Cardim, HJP Rua Joaquim Nabuco,163 Apt 602,Zona 1, BR-87013340 Maringa, Parana, Brazil Rua Joaquim Nabuco,163 Apt 602,Zona 1 Maringa Parana Brazil BR-87013340 BC
Citazione:
H.J.P. Cardim et al., "The insulin-like growth factor-I system and hormone replacement therapy", FERT STERIL, 75(2), 2001, pp. 282-287

Abstract

Objective: To determine the effects of hormone replacement therapy on plasma concentrations of free and total insulin-like growth factor (IGF)-1, IGFbinding protein (BP)-1, and IGFBP-3. Design: Clinical study. Setting: Gynecologic clinic at a university hospital. Patient(s): Seventy-one postmenopausal women. Intervention(s): Six cycles of four different hormonal replacement therapyregimens: oral conjugated estrogens, transdermal estradiol, oral conjugated estrogens and norethisterone, and transdermal estradiol and norethisterone acetate. Main Outcome Measure(s): Blood samples were collected before and after treatment for measurement of free and total IGF-1, IGFBP-1, and IGFBP-3. Result(s): Conjugated estrogen replacement therapy is associated with a decrease in plasma concentration of total IGF-1 and increase in concentrations of free IGF-1 and IGFBP-1. Transdermal estrogens have no effect on total and free IGF-1 and IGFBP-1 concentrations. Oral norethisterone plus conjugated estrogens increased free IGF-1 and IGFBP-1 concentrations but did not change IGF-1 concentrations. Transdermal conjugated estrogens plus norethisterone acetate increased free IGF-1 concentrations but not total IGF-1 or IGFBP-1 concentrations. The plasma concentration of IGFBP-3 did not change inany group. Conclusion(s): Alterations in total IGF-1 concentration can occur depending on the route of hormone replacement therapy administration. Free IGF-1 concentrations were elevated in all study groups except that treated with transdermal estrogens. (C) 2001 by American Society for Reproductive Medicine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:29:42