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Titolo:
Pain behavior and response properties of spinal dorsal horn neurons following experimental diabetic neuropathy in the rat: Modulation by nitecapone, a COMT inhibitor with antioxidant properties
Autore:
Pertovaara, A; Wei, H; Kalmari, J; Ruotsalainen, M;
Indirizzi:
Univ Helsinki, Inst Biomed, Dept Physiol, FIN-00014 Helsinki, Finland UnivHelsinki Helsinki Finland FIN-00014 ol, FIN-00014 Helsinki, Finland Univ Turku, Inst Biomed, Dept Physiol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ept Physiol, FIN-20520 Turku, Finland Orion Corp, Orion Pharma, Drug Discovery & Pharmacol, FIN-02100 Espoo, Finland Orion Corp Espoo Finland FIN-02100 & Pharmacol, FIN-02100 Espoo, Finland
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 167, anno: 2001,
pagine: 425 - 434
SICI:
0014-4886(200102)167:2<425:PBARPO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOL-O-METHYLTRANSFERASE; EXPERIMENTAL PERIPHERAL NEUROPATHY; PROTEIN-KINASE-C; MECHANICAL HYPERALGESIA; REVERSIBLE SPINALIZATION; PERIAQUEDUCTAL GRAY; ANESTHETIZED RATS; NERVE LIGATION; SCIATIC-NERVE; MODEL;
Keywords:
diabetic neuropathy; spinal dorsal horn; mechanical hyperalgesia; tactile allodynia; nitecapone; rostroventromedial medulla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Pertovaara, A Univ Helsinki, Inst Biomed, Dept Physiol, POB 9, FIN-00014 Helsinki, Finland Univ Helsinki POB 9 Helsinki Finland FIN-00014 nki, Finland
Citazione:
A. Pertovaara et al., "Pain behavior and response properties of spinal dorsal horn neurons following experimental diabetic neuropathy in the rat: Modulation by nitecapone, a COMT inhibitor with antioxidant properties", EXP NEUROL, 167(2), 2001, pp. 425-434

Abstract

We attempted to characterize a spinal neuronal correlate of painful neuropathy induced by diabetes mellitus (DM), Pain behavior and response properties of spinal dorsal horn neurons were determined in rats with a streptozocin-induced DM, A catechol-O-methyltransferase inhibitor with potent antioxidant properties, nitecapone, was used in an attempt to attenuate neuropathicsymptoms. Behaviorally DM induced mechanical hypersensitivity that was markedly attenuated by oral treatment with nitecapone, The antihyperalgesic effect of nitecapone was not reversed by naloxone, an opioid antagonist, or atipamezole, an alpha -2-adrenoceptor antagonist. Electrophysiological recordings performed in pentobarbitone-anesthetized animals revealed that the most distinct abnormality in response properties of spinal dorsal horn wide-dynamic range (WDR) neurons was the increase in their spontaneous activity observed in untreated but not in nitecapone-treated DM rats. Conditioning electrical stimulation and a lidocaine block of the rostroventromedial medulla (RVM) had a similar modulatory effect on evoked responses of spinal dorsal horn WDR neurons in all experimental groups. The response properties of spinal dorsal horn nociceptive-specific or low-threshold mechanoreceptive neurons were not markedly different between the experimental groups, The results indicate that increased spontaneous activity in spinal dorsal horn WDR neurons may be causally related to behaviorally observed mechanical hypersensitivity in DM. Attenuation of the increased spontaneous activity in WDR neurons may explain the antihyperalgesic effect by nitecapone, due to naloxone- and alpha -2-adrenoceptor-insensitive mechanisms. DM or nitecapone treatment did not produce significant changes in phasic or tonic descending pain regulation originating in the RVM. (C) 2001 Academic Press.

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Documento generato il 04/06/20 alle ore 01:43:17