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Titolo:
Microdialysis in parkinsonian patient basal ganglia: Acute apomorphine-induced clinical and electrophysiological effects not paralleled by changes inthe release of neuroactive amino acids
Autore:
Fedele, E; Mazzone, P; Stefani, A; Bassi, A; Ansaldo, MA; Raiteri, M; Altibrandi, MG; Pierantozzi, M; Giacomini, P; Bernardi, G; Stanzione, P;
Indirizzi:
Dipartimento Med Sperimentale, Sezione Farmacol & Tossicol, I-16148 Genoa,Italy Dipartimento Med Sperimentale Genoa Italy I-16148 l, I-16148 Genoa,Italy Osped CTO, Div Neurochirurg, I-00146 Rome, Italy Osped CTO Rome Italy I-00146 CTO, Div Neurochirurg, I-00146 Rome, Italy Univ Roma Tor Vergata, Dipartimento Neurosci, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 o Neurosci, I-00133 Rome, Italy IRCCSS, Clin Santa Lucia, I-00179 Rome, Italy IRCCSS Rome Italy I-00179IRCCSS, Clin Santa Lucia, I-00179 Rome, Italy Univ Rome La Sapienza, Ist Clin Malattie Nervose & Mentali, I-00185 Rome, Italy Univ Rome La Sapienza Rome Italy I-00185 & Mentali, I-00185 Rome, Italy
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 2, volume: 167, anno: 2001,
pagine: 356 - 365
SICI:
0014-4886(200102)167:2<356:MIPPBG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO MICRODIALYSIS; SUBTHALAMIC NUCLEUS STIMULATION; LONG-DURATION RESPONSE; ISCHEMIC HUMAN BRAIN; HUMAN HEAD-INJURY; GLOBUS-PALLIDUS; DOPAMINE-RECEPTORS; AUTORADIOGRAPHIC LOCALIZATION; INTRACEREBRAL MICRODIALYSIS; STEREOTAXIC NEUROSURGERY;
Keywords:
Parkinson's disease; microdialysis; apomorphine; endogenous amino acids; basal ganglia; neurosurgery; electrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Fedele, E Dipartimento Med Sperimentale, Sezione Farmacol & Tossicol, Viale Cembrano4, I-16148 Genoa, Italy Dipartimento Med Sperimentale Viale Cembrano 4 Genoa Italy I-16148
Citazione:
E. Fedele et al., "Microdialysis in parkinsonian patient basal ganglia: Acute apomorphine-induced clinical and electrophysiological effects not paralleled by changes inthe release of neuroactive amino acids", EXP NEUROL, 167(2), 2001, pp. 356-365

Abstract

During stereotaxic neurosurgery for deep brain stimulation in Parkinson's disease (PD), we performed a microdialysis study of the extracellular aminoacid (aspartate, glutamate, glycine, and GABA) concentrations. Their levels were measured in the GPe/GPi of five and in the STN of four different PD patients, after prolonged therapy washout. The results show stable values of basal release of the examined amino acids within 1 h, The basal levels ofGABA in "OFF" state were significantly higher in the GPi than in the GPe, Acute apomorphine administration, while inducing clinical amelioration and electrophysiological changes in the examined nuclei, did not change amino acid concentrations. This result could be related to a limited microdialysisability to detect subtle changes in amino acid spontaneous release. Alternatively, it could suggest that dopaminergic receptors located in the outputnuclei, possibly present also in humans, might mediate the acute apomorphine clinical effects, not involving amino acid changes along the direct and/or indirect pathway. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:54:03