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Titolo:
The impact of heart failure on prognosis of diabetic and non-diabetic patients with myocardial infarction: a 15-year follow-up study
Autore:
Melchior, T; Rask-Madsen, C; Torp-Pedersen, C; Hildebrandt, P; Kober, L; Jensen, G;
Indirizzi:
Hillerod Univ Hosp, Dept Cardiol, DK-3400 Hillerod, Denmark Hillerod Univ Hosp Hillerod Denmark DK-3400 l, DK-3400 Hillerod, Denmark Glostrup Univ Hosp, Dept Cardiol, DK-2600 Glostrup, Denmark Glostrup Univ Hosp Glostrup Denmark DK-2600 l, DK-2600 Glostrup, Denmark Gentofte Univ Hosp, Dept Cardiol, DK-2900 Copenhagen, Denmark Gentofte Univ Hosp Copenhagen Denmark DK-2900 K-2900 Copenhagen, Denmark Frederiksberg Hosp, Dept Cardiol & Endocrinol, DK-2000 Frederiksberg, Denmark Frederiksberg Hosp Frederiksberg Denmark DK-2000 Frederiksberg, Denmark
Titolo Testata:
EUROPEAN JOURNAL OF HEART FAILURE
fascicolo: 1, volume: 3, anno: 2001,
pagine: 83 - 90
SICI:
1388-9842(200101)3:1<83:TIOHFO>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR DYSFUNCTION; DEPENDENT TYPE-2 DIABETICS; INSULIN-TREATMENT; SHORT-TERM; MORTALITY; MELLITUS; MORBIDITY; FRAMINGHAM;
Keywords:
diabetes mellitus; heart failure; myocardial infarction; mortality; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Melchior, T Hillerod Univ Hosp, Dept Cardiol, DK-3400 Hillerod, Denmark Hillerod Univ Hosp Hillerod Denmark DK-3400 illerod, Denmark
Citazione:
T. Melchior et al., "The impact of heart failure on prognosis of diabetic and non-diabetic patients with myocardial infarction: a 15-year follow-up study", EUR J HE FA, 3(1), 2001, pp. 83-90

Abstract

Background: Information about the occurrence of heart failure in the acutephase of myocardial infarction (MI) in diabetic patients and its impact onprognosis are sparse. Aim: The purpose of the present study was to describe how MI patients with diabetes mellitus (DM) differed from MI patients without DM with respect to the occurrence of heart failure and with respect tothe influence of heart failure on mortality during follow-up 30 days extending to 15 years. Methods: The study is a retrospective long-term follow-upof prospectively recorded data concerning 1954 consecutive cases of MI admitted to one coronary care unit (CCU) between 1979 and 1983, DM was diagnosed in 10% (n = 194), with 17% (n = 33) on insulin therapy. Patients with DMcomprised of a higher proportion of women (DM 36% vs. no DM 26%, P < 0.001) compared with non-diabetic patients. Baseline risk factors were more prevalent in the patients with DM. The cumulative incidence of heart failure was higher among patients with than without DM (DM 54% vs. no DM 34%, P < 0.001), The incidence of life-threatening arrhythmias were similar in both groups. Only 2% of patients with DM and heart failure survived 10 years of follow-up compared with 15% of the non-diabetic patients with heart failure (P< 0.001). In multivariate analysis DM was not independently associated with 30 days mortality. During long-term follow-up DM was an important risk factor for mortality independent on the presence of heart failure. Conclusion: DM disposes to the development of heart failure. In acute myocardial infarction diabetic patients with heart failure have a worse prognosis than non-diabetic patients with heart failure. (C) 2001 European Society of Cardiology. All rights reserved.

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Documento generato il 04/04/20 alle ore 08:44:55