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Titolo:
Plasma and pericardial fluid natriuretic peptide levels in postinfarction ventricular dysfunction
Autore:
Klemola, R; Tikkanen, I; Vuolteenaho, O; Toivonen, L; Laine, M;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Med, FIN-00250 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00250 ed, FIN-00250 Helsinki, Finland Minerva Fdn, Inst Med Res, FIN-00250 Helsinki, Finland Minerva Fdn Helsinki Finland FIN-00250 Res, FIN-00250 Helsinki, Finland Univ Oulu, Dept Physiol, FIN-90220 Oulu, Finland Univ Oulu Oulu Finland FIN-90220 , Dept Physiol, FIN-90220 Oulu, Finland
Titolo Testata:
EUROPEAN JOURNAL OF HEART FAILURE
fascicolo: 1, volume: 3, anno: 2001,
pagine: 21 - 26
SICI:
1388-9842(200101)3:1<21:PAPFNP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; HEART-FAILURE; MORTALITY; INDICATOR; MARKER;
Keywords:
natriuretic peptides; myocardial infarction; heart failure; ANF; remodelling; hypertrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Laine, M Univ Helsinki, Cent Hosp, Dept Med, FIN-00250 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00250 0250 Helsinki, Finland
Citazione:
R. Klemola et al., "Plasma and pericardial fluid natriuretic peptide levels in postinfarction ventricular dysfunction", EUR J HE FA, 3(1), 2001, pp. 21-26

Abstract

Aims: In the present study we examined plasma and pericardial fluid ANP and BNP concentrations in postinfarction ventricular dysfunction. The association of peptide levels to left ventricular (LV) dysfunction and to the localization of the myocardial infarction (MI) was studied. Methods ann results: Plasma and pericardial fluid samples were obtained from 37 patients undergoing coronary bypass surgery. According to the ECG and preceding coronary angiography, the patients were divided into three groups: previous anteriormyocardial infarction (MI) (n = 12), previous inferior/posterior MI (n = 15) and no history of MI (n = 10). When compared to the control group with no MI, the patients with anterior MI had elevated plasma ANP and BNP (134 +/- 13 vs. 81 +/- 15 pg/ml, P < 0.01 and 95 +/- 10 pg/ml vs. 26 +/- 8 pg/ml, P < 0.01, respectively) and pericardial fluid BNP (473 +/- 60 pg/ml vs. 57 /- 8 pg/ml, P < 0.001) levels. The plasma natriuretic peptide concentrations were not increased in the patients with inferior/posterior MT, but the pericardial fluid BNP concentrations were greater than in the patients with no history of MI (129 +/- 35 pg/ml vs. 57 +/- 8 pg/ml, P < 0.05). Six of the 12 patients with previous anterior MI had LVEF greater than or equal to 45%. Despite their normal LV systolic function, these patients had increasedplasma and pericardial fluid BNP levels when compared to the group with nohistory of MI (68 +/- 18 pg/ml vs. 26 +/- 8 pg/ml, P < 0.05 and 534 +/- 258 pg/ml vs. 57 +/- 8 pg/ml, P < 0.01, respectively). Conclusions: Previous anterior myocardial infarction was associated with increased cardiac BNP production even if the LV systolic function was normal (LVEF greater than or equal to 45%). The high pericardial fluid BNP concentrations in postinfarction patients suggest that the BNP synthesis and release are augmented in the ventricular myocardium independent from the LVEF. (C) 2001 European Society of Cardiology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:23:56