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Titolo:
Plasma N-terminal pro BNP and cardiotrophin-1 are elevated in aortic stenosis
Autore:
Talwar, S; Downie, PF; Squire, IB; Davies, JE; Barnett, DB; Ng, LL;
Indirizzi:
Univ Leicester, Dept Med & Therapeut, Leicester, Leics, England Univ Leicester Leicester Leics England rapeut, Leicester, Leics, England
Titolo Testata:
EUROPEAN JOURNAL OF HEART FAILURE
fascicolo: 1, volume: 3, anno: 2001,
pagine: 15 - 19
SICI:
1388-9842(200101)3:1<15:PNPBAC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN NATRIURETIC PEPTIDE; ACUTE MYOCARDIAL-INFARCTION; IMMUNOLUMINOMETRIC ASSAY; VALVE STENOSIS; HEART-FAILURE; DYSFUNCTION; SECRETION; CYTOKINE;
Keywords:
aortic stenosis; brain natriuretic peptide; cardiotrophin-1; echocardiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ng, LL Leicester Royal Infirm, Dept Med & Therapeut, Robert Kilpatrick Clin Sci Bldg, Leicester LE2 7LX, Leics, England Leicester Royal Infirm RobertKilpatrick Clin Sci Bldg Leicester Leics England LE2 7LX
Citazione:
S. Talwar et al., "Plasma N-terminal pro BNP and cardiotrophin-1 are elevated in aortic stenosis", EUR J HE FA, 3(1), 2001, pp. 15-19

Abstract

Background: Echocardiography with Doppler examination of the aortic valve provides a very accurate assessment of the transvalvular gradient and is used to monitor progression of aortic stenosis (AS). Plasma brain natriureticpeptide (BNP) has been shown to correlate with end-systolic wall stress inpatients with AS. Aim: We hypothesized that plasma N-terminal proBNP (NT proBNP) and a newly identified cytokine cardiotrophin-1 (CT-1), which has been shown to stimulate BNP production at a transcriptional level are elevated in patients with AS and correlate to the maximum trans-valvular aortic pressure gradient (TVPG). Method: We compared plasma NT proBNP and CT-1 in 15AS patients [five males, mean age 79 years [range 60-94], mean TPVG 39.3 mmHg (20-100)] with 10 controls (five male, mean age 68 years [56-79]). Results are expressed as mean [ranges] and comparisons were by the Mann-Whitneytest. Results: NT proBNP levels were elevated in AS patients [252.9 fmol/ml (79.2-541.8)] when compared with the controls (157.2 fmol/ml [104.7-236.9], P < 0.005). Also CT-1 levels were elevated in AS patients (57.3 fmol/ml [33-86.3] when compared with the controls [28.3 fmol/ml (6.9-48.3), P < 0.0005]. Both NT proBNP and CT-1 levels were correlated to the TVPG (r = 0.53 and r = 0.65, P < 0.05 and P = 0.009, respectively). On best subset analysis the strongest correlate with TVPG was CT-1 (R-2 = 38%). The addition of NT proBNP did not improve diagnostic accuracy (R-2 = 39%). Conclusion: Theseresults suggest NT proBNP and CT-1 levels increase in proportion to the TVPG and could potentially be used to monitor progression of disease non-invasively. These markers may also be useful to identify the optimum time for surgery in AS. (C) 2001 European Society of Cardiology. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:47:41