Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Experimental use of an albumin-glutaraldehyde tissue adhesive for sealing pulmonary parenchyma and bronchial anastomoses
Autore:
Herget, GW; Kassa, M; Riede, UN; Lu, Y; Brethner, L; Hasse, J;
Indirizzi:
Univ Freiburg, Dept Thorac Surg, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 c Surg, D-79106 Freiburg, Germany Univ Freiburg, Inst Pathol, D-79104 Freiburg, Germany Univ Freiburg Freiburg Germany D-79104 Pathol, D-79104 Freiburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 1, volume: 19, anno: 2001,
pagine: 4 - 9
SICI:
1010-7940(200101)19:1<4:EUOAAT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SLEEVE LOBECTOMY; COMPLICATIONS; RESECTION; MANAGEMENT; DEHISCENCE; REDUCTION; CARCINOMA; SURGERY; SEALANT; VOLUME;
Keywords:
bronchial anastomosis; lung parenchyma; experimental gluing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Hasse, J Univ Freiburg, Dept Thorac Surg, Hugstetterstr 55, D-79106 Freiburg, Germany Univ Freiburg Hugstetterstr 55 Freiburg Germany D-79106 Germany
Citazione:
G.W. Herget et al., "Experimental use of an albumin-glutaraldehyde tissue adhesive for sealing pulmonary parenchyma and bronchial anastomoses", EUR J CAR-T, 19(1), 2001, pp. 4-9

Abstract

Objective: Despite advanced surgical techniques, major complications of bronchial anastomoses and parenchymal repair, including early leak, fistula formation and granulations still occur. The purpose of this study was to test the performance of an albumin-glutaraldehyde tissue adhesive (BioGlue(R),CryoLife Inc., Kennesaw, GA) as a sealant fur bronchial anastomoses and parenchyma lesions. Methods: Twenty-four sheep were split into two surgical groups. The first group consisted of six control sheep receiving standard sutured bronchial anastomosis with a 4-week end-point. The second group included 18 sheep receiving both a bronchial anastomosis and parenchymal defect repair using the adhesive with 2, 4, and 12 week end-point. Histopathologicevaluation was conducted at the study end-points. Results: Bronchial anastomosis and parenchymal tissue repair can be sealed successfully against airleakage with adhesive. Macroscopic evaluation revealed a tight closure of the anastomosis and parenchyma defect in all postoperative stages, initially by the adhesive layer, and later by connective tissue. On microscopic examination, an inflammatory tissue response consisting of polymorphonuclear neutrophils. macrophages, granulation tissue and foreign body giant cells were found surrounding the glued area after 2 weeks. After 4 weeks the tissueresponse presented a granulomatous character. No granulomatous or foreign body reaction was present in the hand sutured group. After 12 weeks few remnants of adhesive surrounded by fibrous scar tissue were detectable in bronchial anastomosis and parenchymal repair. Healing was not considerably complicated by foreign body reaction or tissue granulation. Conclusion: This study supports BioGlue(R) to be effective as an adjunct in sealing bronchial anastomosis and lung parenchyma defects in sheep, with minimal secondary healing disruptions such as granuloma formation. The results of this study indicate that the use of BioGlue(R) in human pulmonary surgery should be effective. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:26:38