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Titolo:
Hippocampal volume and glucose metabolism in temporal lobe epileptic foci
Autore:
Theodore, WH; Gaillard, WD; De Carli, C; Bhatia, S; Hatta, J;
Indirizzi:
NINDS, Clin Epilepsy Sect, Epilepsy Res Branch, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 lepsy Res Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
EPILEPSIA
fascicolo: 1, volume: 42, anno: 2001,
pagine: 130 - 132
SICI:
0013-9580(200101)42:1<130:HVAGMI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; REGIONAL HYPOMETABOLISM; FDG-PET; SEIZURES; ATROPHY; DENSITY;
Keywords:
epilepsy; hippocampus; glucose metabolism; MRI; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Theodore, WH NINDS, Clin Epilepsy Sect, Epilepsy Res Branch, NIH, Bldg 10,Room 5N-250,10 Ctr Dr,MSC 1408, Bethesda, MD 20892 USA NINDS Bldg 10,Room 5N-250,10 Ctr Dr,MSC 1408 Bethesda MD USA 20892
Citazione:
W.H. Theodore et al., "Hippocampal volume and glucose metabolism in temporal lobe epileptic foci", EPILEPSIA, 42(1), 2001, pp. 130-132

Abstract

Purpose: Reports conflict on the relation of glucose metabolism to hippocampal volume in temporal lobe foci. Previous studies usually have used side-side ratios rather than regional metabolic rates. Methods: We measured hippocampal volume and glucose metabolism in 37 patients with temporal epileptogenic zones identified by ictal video-EEG telemetry. Metabolic rates were normalized to global brain mean. Results: Both 18-fluoro-2-deoxyglucose-PET and volumetric MRI lateralized the epileptic focus determined by ictal video-EEG. There were significant correlations between left-right metabolic asymmetry and hippocampal formation volume left-right ratios. Comparisons between normalized metabolism and hippocampal formation volume, ignoring the side of the epileptic focus, showed significant relations between left hippocampal volume and left inferior lateral temporal metabolism, right hippocampus and right inferior mesial temporal, and left hippocampus and left inferior mesial temporal metabolism. In contrast, when normalized metabolism was compared with hippocampal volume in the epileptic focus, no relation was found. Conclusions. Our study suggests that the relation between hippocampal volume and glucose metabolism breaks down in epileptic foci and that hypometabolism is not dependent on neuronal loss. It is consistent with data suggesting that hypometabolism is an independent predictor of surgical outcome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 00:26:46