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Titolo:
Effect of concurrent anxiety on response to sertraline and imipramine in patients with chronic depression
Autore:
Russell, JM; Koran, LM; Rush, J; Hirschfeld, RMA; Harrison, W; Friedman, ES; Davis, S; Keller, M;
Indirizzi:
Univ Texas, Med Branch, Dept Psychiat & Behav Sci, Galveston, TX 77555 USAUniv Texas Galveston TX USA 77555 at & Behav Sci, Galveston, TX 77555 USA Stanford Univ, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305Stanford Univ, Stanford, CA 94305 USA Univ Texas, SW Med Ctr, Dallas, TX 75230 USA Univ Texas Dallas TX USA 75230 iv Texas, SW Med Ctr, Dallas, TX 75230 USA Pfizer Inc, New York, NY USA Pfizer Inc New York NY USAPfizer Inc, New York, NY USA Columbia Univ, New York, NY USA Columbia Univ New York NY USAColumbia Univ, New York, NY USA Univ Pittsburgh, Sch Med, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ittsburgh, Sch Med, Pittsburgh, PA USA Quintiles, Res Triangle Pk, NC USA Quintiles Res Triangle Pk NC USAQuintiles, Res Triangle Pk, NC USA Brown Univ, Butler Hosp, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 Butler Hosp, Providence, RI 02912 USA
Titolo Testata:
DEPRESSION AND ANXIETY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 18 - 27
SICI:
1091-4269(2001)13:1<18:EOCAOR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE-DISORDER; DOUBLE-BLIND; MAJOR DEPRESSION; PANIC DISORDER; FOLLOW-UP; COMORBIDITY; FLUOXETINE; PLACEBO; TRIAL; OUTPATIENTS;
Keywords:
sertraline; imipramine; anxiety; depression; antidepressive agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Russell, JM Univ Texas, Med Branch, Dept Psychiat & Behav Sci, 301 Univ Blvd,Route 0197, Galveston, TX 77555 USA Univ Texas 301 Univ Blvd,Route 0197 Galveston TX USA 77555 USA
Citazione:
J.M. Russell et al., "Effect of concurrent anxiety on response to sertraline and imipramine in patients with chronic depression", DEPRESS ANX, 13(1), 2001, pp. 18-27

Abstract

Anxiety commonly complicates the clinical presentation of depression and has been associated with poorer long-term outcome, but little information isavailable on the clinical correlates, and comparative effect on treatment response, of subsyndromic or secondary anxiety. Patients diagnosed with chronic major or double depression were randomized to 12 weeks of double-blindtreatment with either sertraline or imipramine in a 2:1 ratio. A high anxiety subgroup was operationally defined by a HAM-D anxiety/somatization factor score greater than or equal to 7. The effect of study treatment was measured utilizing the NAM-D, CGI, HAM-D anxiety/somatization factor as well asa quality of life measure (Q-LES-Q) and a measure of psychosocial functioning (the MOS-SF-36). Two hundred nine patients were treated with imipramineand 426 patients were treated with sertraline. Thirty-six percent of the total met criteria for the high anxiety subgroup. According to Kaplan-Meier probability estimates, patients with significant concurrent anxiety symptoms were more likely to respond by 12 weeks (66.4%) than those without significant anxiety symptoms (54.2%). There was no significant difference in response rates for sertraline vs. imipramine. Both drugs were effective at treating high baseline levels of anxiety, with 60% of sertraline patients and 58% of imipramine patients having 50% or greater reduction from baseline in HAM-D anxiety/somatization factor scores, and only 4.6% and 9.9%, respectively, reporting treatment-emergent worsening in anxiety at study endpoint. Despite the chronicity of depressive illness, acute treatment with both sertraline and imipramine significantly improved psychosocial and quality of life measures. High baseline levels of anxiety did not reduce overall antidepressant response but did somewhat delay the onset of response to sertralineor imipramine in patients with chronic depression. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:43:41