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Titolo:
Oleate, linoleate and cholesterol differently modify aspartyl- and glutamyl-aminopeptidase activities in primary cultures of rat astrocytes
Autore:
Ramirez-Exposito, MJ; Martinez-Martos, JM; Mayas, MD; Garcia, MJ; Prieto, I; Arechaga, G; Ramirez, M;
Indirizzi:
Univ Jaen, Unit Physiol, Fac Expt & Hlth Sci, E-23071 Jaen, Spain Univ Jaen Jaen Spain E-23071 l, Fac Expt & Hlth Sci, E-23071 Jaen, Spain
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 1, volume: 128, anno: 2001,
pagine: 113 - 118
SICI:
1532-0456(200101)128:1<113:OLACDM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENIN-ANGIOTENSIN SYSTEMS; PROTEIN-KINASE-C; FATTY-ACIDS; BRAIN; SECRETION; RECEPTORS; PURIFICATION; METABOLISM; INVITRO; BLOOD;
Keywords:
aminopeptidase A; angiotensinase; astrocytes; cholesterol; linoleate; oleate; primary cultures; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ramirez-Exposito, MJ Univ Jaen, Unit Physiol, Fac Expt & Hlth Sci, Paraje Lagunillas S-N, E-23071 Jaen, Spain Univ Jaen Paraje Lagunillas S-N Jaen Spain E-23071 n
Citazione:
M.J. Ramirez-Exposito et al., "Oleate, linoleate and cholesterol differently modify aspartyl- and glutamyl-aminopeptidase activities in primary cultures of rat astrocytes", COMP BIOC C, 128(1), 2001, pp. 113-118

Abstract

The intake of mono- and polyunsaturated fatty acids has been associated with a minor risk of cardiovascular diseases including hypertension. Changes in levels of fatty acids may also modify the cell activity and may be related with alterations in different regulatory processes. Aminopeptidases are zinc-metalloenzymes which metabolise circulating peptide hormones in several tissues. Glutamyl-aminopeptidase (GluAP) and to a lesser extent, aspartyl-aminopeptidase (AspAP), are related with angiotensin metabolism in the renin-angiotensin system. The present work was designed to study the effect ofa range of concentrations (1-100 muM) of oleic and linoleic acids and cholesterol present in the culture medium on the activity of GluAP and AspAP inthe culture of rat cerebral cortical astrocytes taken from 21-day-old fetuses. The results showed that oleic acid inhibits, while linoleic acid stimulates the activity of AspAP. Both fatty acids inhibit the activity of GluAP. Cholesterol stimulates the activity of both enzymes. On the basis of these results, a functional link may exit between the effects of fatty acids onhypertension and the modulation of aminopeptidase activity by these compounds in rat astrocytes, as an example of target cell type in the central nervous system. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:31:01