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Titolo:
Toxinological and immunological studies of capillary electrophoresis fractionated Chrysaora quinquecirrha (Desor) fishing tentacle and Chironex fleckeri Southcott nematocyst venoms
Autore:
Bloom, DA; Radwan, FFY; Burnett, JW;
Indirizzi:
Univ Maryland Med Syst, Dept Dermatol, Baltimore, MD 21201 USA Univ Maryland Med Syst Baltimore MD USA 21201 ol, Baltimore, MD 21201 USA Univ Maryland, Program Marine Estuarine Environm Sci, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 nvironm Sci, Baltimore, MD 21201 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 1, volume: 128, anno: 2001,
pagine: 75 - 90
SICI:
1532-0456(200101)128:1<75:TAISOC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; JELLYFISH ENVENOMATION; EXPRESSION; CHROMATOGRAPHY; IMMUNITY; PROTEIN; SUBSETS; TOXIN; GAMMA; GENE;
Keywords:
Chironex; Chrysaora; jellyfish; venoms; nematocysts; toxins; hemolysin; lethal factor; capillary electrophoresis; cytosensor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Burnett, JW Univ Maryland Med Syst, Dept Dermatol, 405 W Redwood St,6th Floor, Baltimore, MD 21201 USA Univ Maryland Med Syst 405 W Redwood St,6th Floor Baltimore MD USA 21201
Citazione:
D.A. Bloom et al., "Toxinological and immunological studies of capillary electrophoresis fractionated Chrysaora quinquecirrha (Desor) fishing tentacle and Chironex fleckeri Southcott nematocyst venoms", COMP BIOC C, 128(1), 2001, pp. 75-90

Abstract

Repeated runs of capillary electrophoresis (CE) were used to study partially-purified jellyfish nematocyst venom protein in concentrations sufficientto perform toxinological assays. Nematocyst venoms from Chironex fleckeri (Cf) and Chysaora quinquecirrha were processed. The CE eluate was divided into quadrants by scanning protein content. The fourth fraction of both jellyfish venoms, contained proteins with the smallest molecular weight components, which were responsible for the highest hemolysins and the humoral and cell-mediated immunological activity. Cytotoxic Cf lethal factor activity against human liver cells was widely dispersed throughout both venoms but more prominent in fraction 4. A V-beta receptor human T-cell repertoire was not species-specific for either crude or fractionated jellyfish nematocyst venom. (C) 2001 Elsevier science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:39:47