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Titolo:
The role of glutathion conjugation in the regulation of early toad embryos' tolerance to pesticides
Autore:
Anguiano, OL; de Castro, AC; de DAngelo, AMP;
Indirizzi:
Natl Univ Comahue, Dept Chem, LIBIQUIMA, RA-1400 Buenos Aires, DF, Argentina Natl Univ Comahue Buenos Aires DF Argentina RA-1400 Aires, DF, Argentina
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 1, volume: 128, anno: 2001,
pagine: 35 - 43
SICI:
1532-0456(200101)128:1<35:TROGCI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT SYSTEM; TOXICITY; DIELDRIN;
Keywords:
glutathion; toad embryos; embryotoxicity; GSH S-transferase; pesticide tolerance; oxidative stress; malathion; parathion; lindane; dieldrin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: de D'Angelo, AMP Natl Univ Comahue, Dept Chem, LIBIQUIMA, 8300 Neuquen, RA-1400 Buenos Aires, DF, Argentina Natl Univ Comahue 8300 Neuquen Buenos Aires DF Argentina RA-1400
Citazione:
O.L. Anguiano et al., "The role of glutathion conjugation in the regulation of early toad embryos' tolerance to pesticides", COMP BIOC C, 128(1), 2001, pp. 35-43

Abstract

Reduced glutathion (GSH) content and glutathione S-transferase (GSH S-transferase) activity were investigated in developing toad embryos exposed to parathion, malathion, lindane and dieldrin. The embryonic GSH content was reduced after 96 h of incubation with 20.00 ppm malathion and 2.00 ppm lindane. Parathion and dieldrin did not produce any change. A similar effect was obtained in advanced stages of development (6-days larvae), but only with malathion. No correlation between the decrease in GSH level and mortality ormorphologic abnormalities was observed. The four pesticides increased the activity of GSH S-transferase indicating that the enzyme is susceptible to induction during early development. The higher effect depicted by malathionmay be related with an enhanced conjugation of the pesticide. Both GSH decrease and GSHS- transferase induction modifies the cell redox status and may indirectly influence transcription and translation. The early expression of GST genes provides the embryo with a useful mechanism for the regulationof tolerance against chemical stress. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:53:23