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Titolo:
Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolks
Autore:
Yoshii, H; Tachi, N; Ohba, R; Sakamura, O; Takeyama, H; Itani, T;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Hyg & Occupat Hlth, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Sojo Univ, Fac Engn, Dept Appl Microbial Technol, Kumamoto 8600082, Japan Sojo Univ Kumamoto Japan 8600082 robial Technol, Kumamoto 8600082, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 1, volume: 128, anno: 2001,
pagine: 27 - 33
SICI:
1532-0456(200101)128:1<27:AEOAIO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; SPONTANEOUSLY HYPERTENSIVE RATS; SOLUBILIZATION; PROTEINS; CLARIFICATION; LIPOPROTEINS; SUSPENSIONS; SEPARATION; SYSTEM; RISK;
Keywords:
angiotensin I-converting enzyme (ACE); antihypertensive effect; hypertension; systolic blood pressure; oligopeptides; physiological functional food; egg yolk; spontaneously hypertensive rat (SHR);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Tachi, N Nagoya City Univ, Sch Med, Dept Hyg & Occupat Hlth, Mizuho Ku, 1 Kawasumi,Nagoya, Aichi 4678601, Japan Nagoya City Univ 1 Kawasumi Nagoya Aichi Japan 4678601 601, Japan
Citazione:
H. Yoshii et al., "Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolks", COMP BIOC C, 128(1), 2001, pp. 27-33

Abstract

Oligopeptides of 1 KDa or less were obtained by hydrolysis of chicken egg yolks with a crude enzyme, and by dialysis with a semipermeable membrane filter. Since the extracted peptides had an inhibitory action on the activityof angiotensin I-converting enzyme (ACE) in vitro, they were orally administered at 20, 100 and 500 mg/kg body weight to spontaneously hypertensive rats (SHR) for 12 weeks to analyze the physiological role on cardiovascular functions. The administered oligopeptides suppressed the development of hypertension at all dosages. After 12 weeks at 500 mg/kg body weight, the values for systolic, mean, and diastolic blood pressure were approximately 10% less in SHRs administered than controls. Furthermore, serum ACE activity ofthe peptide-administered groups was significantly lower than that of the control group in a dose-related manner. Our results imply that oligopeptidesextracted from hen's egg yolks could potentially suppress the development of hypertension in SHR, and this effect might be induced by the inhibition of ACE activity. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:43:30