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Titolo:
A possible interaction between CCKergic and GABAergic systems in the rat brain
Autore:
Acosta, GB;
Indirizzi:
Consejo Nacl Invest Cient & Tecn, Inst Invest Farmacol, RA-1113 Buenos Aires, DF, Argentina Consejo Nacl Invest Cient & Tecn Buenos Aires DF Argentina RA-1113 entina
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 1, volume: 128, anno: 2001,
pagine: 11 - 17
SICI:
1532-0456(200101)128:1<11:APIBCA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; BENZODIAZEPINE ANTAGONIST; CEREBRAL-CORTEX; CCK RECEPTOR; AMINO-ACIDS; CHOLECYSTOKININ; RELEASE; ANTIBODIES; AGONISTS; DOPAMINE;
Keywords:
CCK-8S; GABA; PD 135,138; olfactory bulbs; corpus striatum; hippocampus; frontal cerebral cortex; hypothalamus; endogenous levels; rat brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Acosta, GB Consejo Nacl Invest Cient & Tecn, Inst Invest Farmacol, Junin 956,5o Piso,RA-1113 Buenos Aires, DF, Argentina Consejo Nacl Invest Cient & Tecn Junin 956,5o Piso Buenos Aires DF Argentina RA-1113
Citazione:
G.B. Acosta, "A possible interaction between CCKergic and GABAergic systems in the rat brain", COMP BIOC C, 128(1), 2001, pp. 11-17

Abstract

Cholecystokinin sulfated octapeptide (CCK-8S) was given to rats i.p. at single doses of 10 and 100 nmol/kg, respectively. It produced a modification in GABA levels in several areas of the rat brain. After 30 min of injection, the lower dose (10 nmol/kg) increased GABA levels in striatum by 31% (P <0.05). The higher dose (100 nmol/kg) enhanced GABA levels either in hippocampus by 78% (P < 0.05) or in frontal cerebral cortex by 81% (P < 0.05) anddecreased in olfactory bulbs by 57% (P < 0.01). Thus, these results show that systemic injection of CCK-8S, produced regional specific changes on GABA levels in brain, and these effects were dose-dependent. Systemic pretreatment with the CCKB receptor antagonist, PD 135,158, 1 mg/kg i.p., on the endogenous levels of GABA in certain regions was also studied. The selective CCKB receptor antagonist, PD 135,158, did not have an effect per sc on the endogenous levels of GABA but prevents the action induced by the neuropeptide. We suggest that the action of CCK may be mediated via a selective action on the CCKB receptor subtypes. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 00:14:39