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Titolo:
Parenteral nutrition and cyclosporine: do lipids make a difference? A prospective randomized crossover trial
Autore:
Santos, P; Lourenco, R; Camilo, ME; Oliveira, AG; Figueira, I; Pereira, ME; Ferreira, B; Carmo, JA; Lacerda, JMF;
Indirizzi:
Univ Hosp Santa Maria, Ctr Nutr & Metab, Lisbon, Portugal Univ Hosp Santa Maria Lisbon Portugal tr Nutr & Metab, Lisbon, Portugal Univ Hosp Santa Maria, Bone Marrow Transplant Unit, Lisbon, Portugal Univ Hosp Santa Maria Lisbon Portugal Transplant Unit, Lisbon, Portugal
Titolo Testata:
CLINICAL NUTRITION
fascicolo: 1, volume: 20, anno: 2001,
pagine: 31 - 36
SICI:
0261-5614(200102)20:1<31:PNACDL>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; DRUG-THERAPY; PHARMACOKINETICS; HYPERTRIGLYCERIDEMIA; ENERGY; NEED;
Keywords:
cyclosporine; parenteral nutrition; lipid emulsions; bone marrow transplantation; pharmacokinetics; randomized crossover trial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Camilo, ME Hosp Santa Maria, Fac Med Lisboa, Ctr Nutr & Metab, Av Egas Moniz, P-1649028 Lisbon, Portugal Hosp Santa Maria Av Egas Moniz Lisbon Portugal P-1649028 tugal
Citazione:
P. Santos et al., "Parenteral nutrition and cyclosporine: do lipids make a difference? A prospective randomized crossover trial", CLIN NUTR, 20(1), 2001, pp. 31-36

Abstract

Aims: This prospective, controlled, randomized crossover trial was conducted to assess the effects of parenteral nutrition, with or without lipids, in cyclosporine (CyA) pharmacokinetics. Methods: 10 adult patients were randomized on the day of allogeneic bone marrow transplantation to receive isocaloric and isonitrogenous parenteral nutrition admixtures without (regimen A) or with lipids (regimen B). Admixtures were started on average by day + 7.4; 5 patients received regimen A followed by B, 5 in reverse order. Blood samples were collected at day 4 aftertransplantation, under oral diet, and 4 days after the initiation of each regimen as the sole nutrition support. At each time point, 8 whole blood samples were analysed for CyA to evaluate: area under the curve (AUC), troughconcentration and systemic clearance. Clinical/laboratory events were recorded until 31 months of follow-up. Results: There was no evidence of a period or treatment-by period interaction, thus results were combined for further analysis. There were no statistically significant differences between regimens in any CyA pharmacokinetic parameters; there were no significant differences from baseline values, except for a higher systemic clearance of CyA with regimen A (0.40 +/- 0.09 vs0.29 +/- 0.06 L/Kg/h, p=0.03). Conclusions:The provision of 0.8 g/Kg/d of a 50:50 mixture of medium and long chain triglycerides did not affect CyA parameters, which were closer tobaseline. In the short or long term there were no attributable side effects. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:55:03