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Titolo:
The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytes
Autore:
Owens, GP; Burgoon, MP; Anthony, J; Kleinschmidt-DeMasters, BK; Gilden, DH;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Neurol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Neurol, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Dept Pathol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Pathol, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Dept Microbiol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 r, Dept Microbiol, Denver, CO 80262 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 98, anno: 2001,
pagine: 258 - 263
SICI:
1521-6616(200102)98:2<258:TIGHCR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLONAL EXPANSION; B-CELLS; BRAIN;
Keywords:
MS brain plaques; peripheral blood lymphocytes; compartmentalized B cell response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Owens, GP Univ Colorado, Hlth Sci Ctr, Dept Neurol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Neurol, Denver, CO 80262 USA
Citazione:
G.P. Owens et al., "The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytes", CLIN IMMUNO, 98(2), 2001, pp. 258-263

Abstract

Analyses have shown that the repertoire of Ig heavy chain sequences (VH) expressed in multiple sclerosis (MS) plaques or cerebrospinal fluid is consistent with B cell clonal expansion and affinity maturation. PCR amplification of VH sequences from RIS lesions obtained from an acute MS patient at autopsy revealed oligoclonal and extensively mutated VH sequences from plaque-periplaque regions with discrete intraclonal differences indicative of B cell clonal expansion in the groups of overrepresented major sequences. Noneof the VH sequences expressed in plaque regions were detected in peripheral blood lymphocytes from this patient. These data indicate the presence of a CNS-targeted antigen-driven response in MS plaques. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 09:11:09