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Titolo:
Autoantibodies to the 20-kDa ribosomal proteins: Identification, characterization, and new aspects on prevalence in systemic lupus erythematosus
Autore:
Anderson, CJ; Neas, BR; Uchiumi, T; Stafford, HA;
Indirizzi:
Oklahoma Med Res Fdn, Arthrit & Immunol Program, Oklahoma City, OK 73104 USA Oklahoma Med Res Fdn Oklahoma City OK USA 73104 lahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK 73104 USA Univ Oklahoma Oklahoma City OK USA 73104 iol, Oklahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK 73104 USA Univ Oklahoma Oklahoma City OK USA 73104 Med, Oklahoma City, OK 73104 USA Dept Vet Affairs, Arthrit & Immunol Program, OMRF, Oklahoma City, OK 73104USA Dept Vet Affairs Oklahoma City OK USA 73104 F, Oklahoma City, OK 73104USA Shinshu Univ, Inst High Polymer Res, Ueda, Nagano 3868567, Japan Shinshu Univ Ueda Nagano Japan 3868567 r Res, Ueda, Nagano 3868567, Japan
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 2, volume: 98, anno: 2001,
pagine: 249 - 257
SICI:
1521-6616(200102)98:2<249:ATT2RP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
P-PROTEINS; HIGH-FREQUENCY; MRL/LPR MICE; ANTIBODIES; RNA; ASSOCIATION; DISEASE; S10; SM; ANTIGENS;
Keywords:
autoantibodies; autoimmunity; humans; ribosomal proteins; anti-ribosomal antibodies; anti-ribosommal P antibodies; anti-L12 antibodies; anti-S10 antibodies; systemic lupus erythematosus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Stafford, HA Oklahoma Med Res Fdn, Arthrit & Immunol Program, 825 NE 13th St,MS 24, Oklahoma City, OK 73104 USA Oklahoma Med Res Fdn 825 NE 13th St,MS 24 Oklahoma City OK USA 73104
Citazione:
C.J. Anderson et al., "Autoantibodies to the 20-kDa ribosomal proteins: Identification, characterization, and new aspects on prevalence in systemic lupus erythematosus", CLIN IMMUNO, 98(2), 2001, pp. 249-257

Abstract

Autoantibodies to the 20-kDa ribosomal proteins (L12/S10) are not well studied, especially in juveniles with systemic lupus erythematosus (SLE). Randomly selected sera from American juveniles and adults with SLE were screened for antibodies to either 20-kDa protein and P proteins and then assayed for anti-L12 and anti-S10 by immunoblot assays, In a pilot study of patientswith anti-P (Cohort 1), IgG antibodies to either 20-kDa protein and, specifically, to L12 were observed in 72 and 42% of juveniles and adults, respectively. IgG antibodies to S10 were detected less frequently. In Cohort 2 patients who were chosen irrespective of autoantibody status, twice as many juveniles as adults had IgG antibodies to either 20-kDa protein. Prevalencesof IgG anti-L12 and IgG anti-S10 antibodies in the juveniles were 28 and 16% and in the adults were 13 and 12%, respectively. Anti-L12 were strongly but not invariably associated with anti-P, and usually arose temporally to these antibodies. Anti-S10 activity was due to anti-Sm antibodies, We conclude that IgG anti-L12 are more prevalent in SLE than previously reported, and are responsible for the majority of activity toward the 20-kDa ribosomalproteins, especially in juveniles. (C) 2000 Academic Press.

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Documento generato il 12/12/19 alle ore 14:57:02