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Titolo:
Erythrocyte superoxide dismutase and glutathione peroxidase activities, and malondialdehyde and reduced glutathione levels in schizophrenic patients
Autore:
Altuntas, I; Aksoy, H; Coskun, I; Caykoylu, A; Akcay, F;
Indirizzi:
Ataturk Univ, Sch Med, Dept Biochem, TR-25240 Erzurum, Turkey Ataturk Univ Erzurum Turkey TR-25240 t Biochem, TR-25240 Erzurum, Turkey Ataturk Univ, Sch Med, Dept Psychiat, TR-25240 Erzurum, Turkey Ataturk Univ Erzurum Turkey TR-25240 Psychiat, TR-25240 Erzurum, Turkey
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 12, volume: 38, anno: 2000,
pagine: 1277 - 1281
SICI:
1434-6621(200012)38:12<1277:ESDAGP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT DEFENSE SYSTEM; CENTRAL-NERVOUS-SYSTEM; LIPID-PEROXIDATION; PSYCHOSIS; ENZYMES; INJURY;
Keywords:
schizophrenia; antioxidants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Akcay, F Ataturk Univ, Sch Med, Dept Biochem, TR-25240 Erzurum, Turkey Ataturk Univ Erzurum Turkey TR-25240 , TR-25240 Erzurum, Turkey
Citazione:
I. Altuntas et al., "Erythrocyte superoxide dismutase and glutathione peroxidase activities, and malondialdehyde and reduced glutathione levels in schizophrenic patients", CLIN CH L M, 38(12), 2000, pp. 1277-1281

Abstract

There is abundant evidence that free radicals are involved in membrane pathology in the central nervous system and that they may play a role in neuropsychiatric disorders, including schizophrenia. In this study, we investigated erythrocyte superoxide dismutase and glutathione peroxidase activities as antioxidant enzymes, malondialdehydes as a sign of lipid peroxidation, and reduced glutathione levels in schizophrenic patients. Activities of superoxide dismutase and levels of malondialdehyde in erythrocytes were greaterin all patients (n=48) and in patients with acute (n=16) and chronic schizophrenia (n=32) (p<0.001 for all patients and chronic patient group; p<0.05for acute patient group). The activities of glutathione peroxidase were lower in patients (p<0.05 for all patients and acute patient group; p=0.051 for chronic patient group) compared with the control group. Mean erythrocytereduced glutathione was lower in patients than in controls (p<0.05). In the patient group, erythrocyte superoxide dismutase activity was positively correlated with scales and duration of disease and erythrocyte malondialdehyde concentration. These data reveal that antioxidative defense mechanisms might be impaired in schizophrenic patients.

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Documento generato il 02/07/20 alle ore 22:04:00