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Titolo:
Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue
Autore:
Lappin, DF; Macleod, CP; Kerr, A; Mitchell, T; Kinane, DF;
Indirizzi:
Glasgow Dent Hosp & Sch, Unit Periodontol, Periodontol & Oral Immunol Grp,Glasgow G2 3JZ, Lanark, Scotland Glasgow Dent Hosp & Sch Glasgow Lanark Scotland G2 3JZ , Lanark, Scotland Univ Glasgow, Inst Biomed & Life Sci Infect & Immun, Glasgow, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland & Immun, Glasgow, Lanark, Scotland
Titolo Testata:
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
fascicolo: 2, volume: 123, anno: 2001,
pagine: 294 - 300
SICI:
0009-9104(200102)123:2<294:ACIATC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORPHYROMONAS-GINGIVALIS; PERIPHERAL-BLOOD; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; CREVICULAR FLUID; IMMUNE-RESPONSE; DISEASE; SUBSETS; GAMMA; TH1; HETEROGENEITY;
Keywords:
periodontitis; leucocyte infiltrate; T cell; B cell; macrophage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kinane, DF Glasgow Dent Hosp & Sch, Unit Periodontol, Periodontol & Oral Immunol Grp,378 Sauchiehall St, Glasgow G2 3JZ, Lanark, Scotland Glasgow Dent Hosp & Sch 378 Sauchiehall St Glasgow Lanark Scotland G2 3JZ
Citazione:
D.F. Lappin et al., "Anti-inflammatory cytokine IL-10 and T cell cytokine profile in periodontitis granulation tissue", CLIN EXP IM, 123(2), 2001, pp. 294-300

Abstract

Th2 cells are more abundant than Th1 cells in periodontitis lesions, but the relative importance of the Th1 and Th2 subsets in periodontal disease isnot understood. In addition, the role of proinflammatory and anti-inflammatory cytokines in this disease process is unclear. Biopsies were obtained from 10 patients with early onset periodontitis (EOP) and 10 patients with adult periodontitis (AP). From all of the patients in the AP group we were able to obtain and section the gingival tissue to serve as controls. We usedpolyclonal monospecific antibodies to detect cells expressing IL-2, IL-4, IL-6, IL-10 and IL-15, tumour necrosis factor (TNF-alpha) and interferon-gamma (IFN-gamma) in formalin-fixed, paraffin-embedded sections of granulation tissue from periodontitis lesions. We also employed a series of oligonucleotide probes to detect cells expressing the cytokine transcripts in the same tissue biopsies. Cells that expressed IL-4 or IL-6 were more numerous than cells expressing either IL-2 or IFN-gamma. Th2 cells were more numerous in EOP and AP tissues. IL-15 substitutes for IL-2 in a number of biologicalactivities related to the Th1 immune response, and interestingly, in periodontal lesions the IL-15-expressing cells outnumbered IL-2-expressing cells, suggesting that this is the pattern of immune regulation by T cells in the periodontium. The functional balance in the T cell subsets detected by their cytokine profiles underlies the importance of the anti-inflammatory mechanisms taking place in the diseased tissue. The numbers of inflammatory leucocytes that express the anti-inflammatory cytokine IL-10 are much more widely distributed than those that express the proinflammatory cytokines IL-6and TNF-alpha. This study suggests that large numbers of infiltrating inflammatory cells as well as accessory cells are involved in the down-regulation of the inflammatory and immune response in periodontitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:48:08