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Titolo:
Regular inhaled salbutamol - Effect on airway responsiveness to methacholine and adenosine 5 '-monophosphate and tolerance to bronchoprotection
Autore:
Jokic, R; Swystun, VA; Davis, BE; Cockcroft, DW;
Indirizzi:
Univ Saskatchewan, Div Resp Med, Dept Med, Royal Univ Hosp, Saskatoon, SK S7N 0W8, Canada Univ Saskatchewan Saskatoon SK Canada S7N 0W8 skatoon, SK S7N 0W8, Canada
Titolo Testata:
CHEST
fascicolo: 2, volume: 119, anno: 2001,
pagine: 370 - 375
SICI:
0012-3692(200102)119:2<370:RIS-EO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL RESPONSIVENESS; ALLERGEN CHALLENGE; ASTHMA; HISTAMINE; SALMETEROL; REACTIVITY; ALBUTEROL; BRONCHOCONSTRICTION; HYPERRESPONSIVENESS; INFLAMMATION;
Keywords:
adenosine 5 '-monophosphate; airway hyperresponsiveness; asthma; beta(2)-agonists; bronchoprotection; methacholine; tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Cockcroft, DW Univ Saskatchewan, Div Resp Med, Dept Med, Royal Univ Hosp, 103 Hosp Dr,Ellis Hall, Saskatoon, SK S7N 0W8, Canada Univ Saskatchewan 103Hosp Dr,Ellis Hall Saskatoon SK Canada S7N 0W8
Citazione:
R. Jokic et al., "Regular inhaled salbutamol - Effect on airway responsiveness to methacholine and adenosine 5 '-monophosphate and tolerance to bronchoprotection", CHEST, 119(2), 2001, pp. 370-375

Abstract

Objective: Regular treatment with inhaled beta (2)-agonists increases airway responsiveness consistently to indirect bronchoconstrictors (allergen, exercise, hypertonic saline solution, etc) and inconsistently to direct bronchoconstrictors (histamine, methacholine), Studies demonstrating tolerance to beta (2)-agonist bronchoprotection against the indirect bronchoconstrictor adenosine 5'-monophosphate (AMP) have not examined changes in baseline AMP responsiveness. This study assessed the effect of regular salbutamol on AMP and methacholine responsiveness and on tolerance to bronchoprotection. Design: Double-blind, randomized, crossover study. Setting: University hospital bronchoprovocation laboratory. Patients: Fourteen atopic asthmatic subjects with FEV1 > 65% predicted, and methacholine provocative concentration causing a 20% fall in FEV1 (PC20) < 8 mg/mL. Interventions: Salbutamol, 100 <mu>g, and placebo inhalers, mo puffs qid, each for 10 days. Measurements: Methacholine PC20 and AMP PC20 measured 12 h after blinded inhaler after each (eight subjects). Results: There was no difference between placebo and salbutamol treatment in geometric mean methacholine PC20 (0.85 mg/mL vs 0.82 mg/mL, p = 0.86) orAMP PC20 (22 mg/mL vs 17.4 mg/mL, p = 0.21; n = 14), The acute bronchoprotective effect of salbutamol was greater vs AMP than vs methacholine (5.1 doubling concentrations vs 3.5 doubling concentrations, p = 0.06) and loss ofprotective effect of salbutamol (mean +/- SD) was greater vs AMP than vs methacholine (2.4 +/- 0.33 doubling concentration loss vs 0.8 +/- 0.21 doubling concentration loss, p = 0.008; n = 8),Conclusion: Regular salbutamol (mean +/- SD) treatment did not enhance airway responsiveness to either the indirect bronchoconstrictor AMP or the direct bronchoconstrictor methacholine, Compared to its effect on methacholine, salbutamol had a greater acute protective effect vs AMP and produced greater loss of protection vs AMP when used regularly.

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Documento generato il 16/02/20 alle ore 23:28:58