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Titolo:
Asymmetric activation of chiral alkoxyzinc catalysts by chiral nitrogen activators for dialkylzinc addition to aldehydes: Super high-throughput screening of combinatorial libraries of chiral ligands and activators by HPLC-CD/UV and HPLC-OR/RIU systems
Autore:
Mikami, K; Angelaud, R; Ding, KL; Ishii, A; Tanaka, A; Sawada, N; Kudo, K; Senda, M;
Indirizzi:
Tokyo Inst Technol, Fac Engn, Dept Chem Technol, Tokyo 1528552, Japan Tokyo Inst Technol Tokyo Japan 1528552 hem Technol, Tokyo 1528552, Japan Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200032 200032, Peoples R China Fujisawa Pharmaceut Co Ltd, Basic Res Lab, Osaka 5328514, Japan Fujisawa Pharmaceut Co Ltd Osaka Japan 5328514 Lab, Osaka 5328514, Japan Dainippon Seiki Co Ltd, Sci Machinery Div, Kyoto 617, Japan Dainippon Seiki Co Ltd Kyoto Japan 617 i Machinery Div, Kyoto 617, Japan JASCO Corp, Liquid Chromatog Div, Tokyo 1928537, Japan JASCO Corp Tokyo Japan 1928537 iquid Chromatog Div, Tokyo 1928537, Japan
Titolo Testata:
CHEMISTRY-A EUROPEAN JOURNAL
fascicolo: 3, volume: 7, anno: 2001,
pagine: 730 - 737
SICI:
0947-6539(20010202)7:3<730:AAOCAC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIELS-ALDER REACTIONS; HIGH ENANTIOMERIC PURITIES; GLYOXYLATE ENE REACTION; ALPHA-HYDROXY ESTERS; BETA-AMINO ALCOHOLS; ENANTIOSELECTIVE ADDITION; LIQUID-CHROMATOGRAPHY; ORGANOZINC REAGENTS; ORGANIC-SYNTHESIS; LEWIS-ACIDS;
Keywords:
asymmetric activation; asymmetric catalysis; binaphthol; combinatorial chemistry; zinc;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
117
Recensione:
Indirizzi per estratti:
Indirizzo: Mikami, K Tokyo Inst Technol, Fac Engn, Dept Chem Technol, Tokyo 1528552, Japan Tokyo Inst Technol Tokyo Japan 1528552 l, Tokyo 1528552, Japan
Citazione:
K. Mikami et al., "Asymmetric activation of chiral alkoxyzinc catalysts by chiral nitrogen activators for dialkylzinc addition to aldehydes: Super high-throughput screening of combinatorial libraries of chiral ligands and activators by HPLC-CD/UV and HPLC-OR/RIU systems", CHEM-EUR J, 7(3), 2001, pp. 730-737

Abstract

Asymmetric catalysts, prepared by chiral ligand exchange or chiral modification, can evolve further into highly activated catalysts through engineering with chiral activators. Two new methodologies for "super high-throughputscreening" (SHTS) of chiral ligands and activators have been developed as a combination of HPLC-CD/UV (CD/UV=circular dichroism/ultraviolet spectroscopy) or -OR/RIU (OR/RIU = optical rotation/refractive index unit) with a combinatorial chemistry (CC) factory. With these techniques, the % ee of the product is determined within minutes without separation of the enantiomericproducts by using a nonchiral stationary phase. Therefore, those SHTS techniques combined with our 'asymmetric activation' concept can provide a powerful strategy for finding the best activated chiral catalyst.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:03:33