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Titolo:
Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China
Autore:
Wang, JS; Huang, T; Su, JJ; Liang, F; Wei, ZL; Liang, YQ; Luo, HT; Kuang, SY; Qian, GS; Sun, GJ; He, X; Kensler, TW; Groopman, JD;
Indirizzi:
Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Environm Hlth Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 th Sci, Baltimore, MD 21205 USA Guangxi Canc Inst, Nanning, Guangxi, Peoples R China Guangxi Canc Inst Nanning Guangxi Peoples R China angxi, Peoples R China Fusui Liver Canc Inst, Fusui, Guangxi, Peoples R China Fusui Liver Canc Inst Fusui Guangxi Peoples R China gxi, Peoples R China Shanghai Canc Inst, Shanghai, Peoples R China Shanghai Canc Inst Shanghai Peoples R China , Shanghai, Peoples R China
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 2, volume: 10, anno: 2001,
pagine: 143 - 146
SICI:
1055-9965(200102)10:2<143:HCAAEI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-LIVER-CANCER; HEPATITIS-B VIRUS; OF-CHINA; ALBUMIN ADDUCTS; P53 GENE; BIOMARKERS; GUANGXI; QIDONG; RISK; EPIDEMIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, JS Texas Tech Univ Syst, Inst Environm & Human Hlth, Box 41163, Lubbock, TX 79409 USA Texas Tech Univ Syst Box 41163 Lubbock TX USA 79409 TX 79409 USA
Citazione:
J.S. Wang et al., "Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China", CANC EPID B, 10(2), 2001, pp. 143-146

Abstract

Hepatocellular carcinoma (HCC) is a common cause of cancer morbidity and mortality in Asia and Africa. Epidemiological studies have found that dietary exposure to aflatoxin B-1 (AFB(1)) and chronic infection with hepatitis Bvirus are two major risk factors for HCC, We have collated the incidence and mortality data of malignant tumors from 1973 to 1999 in Zhuqing Village,Fusui County, an area with very high HCC rates, and found that this canceraccounted for 64% of the total cancer incidence. Dietary intake of AFB(1) was monitored for 1 week in a study group consisting of 15 males and 14 females from different households in this village. Four of 29 participants (13.8%) and 3 of 15 (20%) male participants were hepatitis B virus surface antigen positive. AFB(1) was detectable in 76.7% (23 of 30) of ground corn samples (range, 0.4-128.1 ppb), 66.7% (20 of 30) of cooking peanut oil samples(range, 0.1-52.5 ppb), and 23.3% (7 of 30) of rice samples (range, 0.3-2.0ppb) collected from each household. Mean levels of serum AFB(1)-albumin adducts in this group were 1.24 +/- 0.31 pmol/mg of albumin at the beginning of the study and 1.21 +/- 0.19 pmol/mg of albumin at the end of the period. Urinary AFB(1) metabolites were detectable in 88.9% (24 of 27) samples (range, 0.9-3569.7 ng/24-h urine), These data provide the exposure and diseaserisk information for establishing intervention studies to diminish the impact of aflatoxin exposure in this high-risk population.

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Documento generato il 30/10/20 alle ore 23:36:48