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Titolo:
Screening markers for chronic atrophic gastritis in Chiapas, Mexico
Autore:
Ley, C; Mohar, A; Guarner, J; Herrera-Goepfert, R; Figueroa, LS; Halperin, D; Parsonnet, J;
Indirizzi:
Stanford Univ, Dept Hlth Res & Policy, Div Epidemiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Div Epidemiol, Stanford, CA 94305 USA Stanford Univ, Dept Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USAStanford Univ Stanford CA USA 94305 is & Geog Med, Stanford, CA 94305 USA Inst Nacl Cancerol, Mexico City 14000, DF, Mexico Inst Nacl Cancerol Mexico City DF Mexico 14000 ico City 14000, DF, Mexico UNAM, Inst Invest Biomed, Mexico City 14000, DF, Mexico UNAM Mexico City DF Mexico 14000 st Biomed, Mexico City 14000, DF, Mexico Ctr Dis Control & Prevent, Infect Dis Pathol Act, Atlanta, GA 30333 USA Ctr Dis Control & Prevent Atlanta GA USA 30333 Act, Atlanta, GA 30333 USA Colegio Frontera Sur, Div Poblac & Salud, San Cristobal De Casas 29290, Chiapas, Mexico Colegio Frontera Sur San Cristobal De Casas Chiapas Mexico 29290 , Mexico
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 2, volume: 10, anno: 2001,
pagine: 107 - 112
SICI:
1055-9965(200102)10:2<107:SMFCAG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI INFECTION; SERUM PEPSINOGEN LEVELS; HIGH-RISK; PERNICIOUS-ANEMIA; LESIONS; CANCER; POPULATION; ASSOCIATION; ANTIBODIES; RELATIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ley, C Stanford Univ, Dept Hlth Res & Policy, Div Epidemiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 demiol, Stanford, CA 94305 USA
Citazione:
C. Ley et al., "Screening markers for chronic atrophic gastritis in Chiapas, Mexico", CANC EPID B, 10(2), 2001, pp. 107-112

Abstract

Intestinal-type gastric adenocarcinomas usually are preceded by chronic atrophic gastritis, Studies of gastric cancer prevention often rely on identification of this condition. In a clinical trial, we sought to determine thebest serological screening method for chronic atrophic gastritis and compared our findings to the published literature. Test characteristics of potential screening tests (antibodies to Helicobacter pylori or CagA, elevated gastrin, low pepsinogen, increased age) alone or in combination were examined among consecutive subjects enrolled in a study of H. pylori and preneoplastic gastric lesions in Chiapas, Mexico; 70% had chronic atrophic gastritis, English-language articles concerning screening for chronic atrophic gastritis were also reviewed. Sensitivity for chronic atrophic gastritis was highest for antibodies to H. pylori (92%) or CagA, or gastrin levels >25 ng/l (both 83%), Specificity, however, was low for these tests (18, 41, and 22%,respectively). Pepsinogen levels were highly specific but insensitive markers of chronic atrophic gastritis (for pepsinogen I<25 <mu>g/l, sensitivitywas 6% and specificity was 100%; for pepsinogen I:pepsinogen II ratio <2.5, sensitivity was 14% and specificity was 96%), Combinations of markers didnot improve test characteristics. Screening test characteristics from the literature varied widely and did not consistently identify a good screeningstrategy. In this study, CagA antibodies alone had the best combination oftest characteristics for chronic atrophic gastritis screening. However, noscreening test was both highly sensitive and highly specific for chronic atrophic gastritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:56:36