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Titolo:
Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin
Autore:
Yam, D; Peled, A; Shinitzky, M;
Indirizzi:
Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 Chem, IL-76100 Rehovot, Israel
Titolo Testata:
CANCER CHEMOTHERAPY AND PHARMACOLOGY
fascicolo: 1, volume: 47, anno: 2001,
pagine: 34 - 40
SICI:
0344-5704(200101)47:1<34:SOTGAM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYUNSATURATED FATTY-ACIDS; LEWIS LUNG-CARCINOMA; RAT MAMMARY-TUMOR; COLON-CANCER; NUDE-MICE; CELLS; SUPPLEMENTATION; ADENOCARCINOMA; INCREASE; N-3;
Keywords:
Omega-3 PUFA; lipid peroxidation; tumor suppression; chemotherapy; vitamins E plus C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Shinitzky, M Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 0 Rehovot, Israel
Citazione:
D. Yam et al., "Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin", CANC CHEMOT, 47(1), 2001, pp. 34-40

Abstract

Purpose: The anticancer activity of Ohm -3 poly unsaturated fatty acids (Ohm -3 PUFA) has been shown in a large number of studies. This study was undertaken to analyze the combined effect of Ohm -3 PUFA and antioxidative vitamins on the level of spontaneous metastatic dissemination. The supportive effect of this dietary combination on chemotherapy with cisplatin (CP) was determined in parallel. Methods: C57BL/6J mice bearing the Lewis lung carcinoma 3LL were fed ad libitum one of three isocaloric diets containing 5% soybean oil supplemented with 40 mg/kg alpha -tocopherol acetate (SO diet), or 4% fish oil plus 1% corn oil, and basal amounts of vitamin E (FO diet) orFO diet supplemented with vitamins E and C (FO+E+C diet). These diets weretested in combination with the conventional cytotoxic agent CP in a seriesof regimens. Tumor growth, feed consumption, body weight, lung metastasis and lung histology were followed. Results: Both the FO dietary groups showed significantly lower tumor development than the SO group in all examined parameters, indicating that Ohm -3 PUFA have anticancer activity. However, the FO diet, in comparison with the FO+E+C diet induced a significantly slower rate of tumor growth, and lower metastatic load, as reflected in lung weight. The decrease in the anticancer activity of FO by the addition of vitamins E and C suggests that in situ oxidation of Ohm -3 PUFA underlies theiranticancer action. It is thus proposed that oxidized Ohm -3 PUFA accumulates in the membranes and the cytosol of tumor cells, reducing their vitalityand eventually leading to their death. No signs of anorexia or cachexia were observed in either FO group, in contrast to the SO group. CP treatment with the SO diet had no apparent therapeutic effect, while with the FO dietsit reduced the metastatic load. The best regimen of this combined treatment was FO diet followed by CP treatment with FO diet supplemented with vitamins E and C after resection of the primary growth. This regimen could be translated to a combined therapy for human cancer. Conclusions: Diets enriched with Ohm -3 PUFA may have beneficial anticancer effects in particular when containing only basal amounts of antioxidants such as vitamin E or C. Furthermore, the addition of drugs which promote oxidation of Ohm -3 PUFA, such as ferrous salts (e.g. as prescribed for the treatment of anemia), may further increase these effects. However, the supportive effect of Ohm -3 PUFAin chemotherapy (e.g. with CP) increases when vitamins E and C are also included.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:40:18