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Titolo:
Gastric acid secretory response in Helicobacter pylori-positive patients with duodenal ulcer disease
Autore:
Jacobson, K; Chiba, N; Chen, Y; Barrientos, M; James, C; Riddell, RH; Hunt, RH;
Indirizzi:
McMaster Univ, Med Ctr, Dept Med, Div Gastroenterol, Hamilton, ON L8N 3Z5,Canada McMaster Univ Hamilton ON Canada L8N 3Z5 rol, Hamilton, ON L8N 3Z5,Canada
Titolo Testata:
CANADIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 1, volume: 15, anno: 2001,
pagine: 29 - 39
SICI:
0835-7900(200101)15:1<29:GASRIH>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARIETAL-CELL SENSITIVITY; DOUBLE-BLIND TRIAL; FOLLOW-UP; PENTAGASTRIN STIMULATION; CAMPYLOBACTER PYLORI; HEALTHY-SUBJECTS; PEPTIC-ULCER; ERADICATION; SOMATOSTATIN; INFECTION;
Keywords:
duodenal ulcer; gastric acid secretion; Helicobacter pylori;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Hunt, RH Hamilton Hlth Sci Corp, McMaster Div, Div Gastroenterol, Room 4W8,1200 Mail St W, Hamilton, ON L8N 3Z5, Canada Hamilton Hlth Sci Corp Room 4W8,1200 Mail St W Hamilton ON Canada L8N 3Z5
Citazione:
K. Jacobson et al., "Gastric acid secretory response in Helicobacter pylori-positive patients with duodenal ulcer disease", CAN J GASTR, 15(1), 2001, pp. 29-39

Abstract

BACKGROUND: Patients with duodenal ulcer (DU) have an increased parietal cell mass and sensitivity to secretagogues, with increased acid output. AIM:To determine the effect of Helicobacter pylori eradication on parietal cell sensitivity and gastric acid secretion. SUBJECTS AND METHODS: Twenty-five H pylori-positive DU patients and 18 H pylori-negative healthy volunteers were studied. Serum H pylori immunoglobulin G, basal acid output and acid secretory response to graded doses of pentagastrin were determined before and after treatment, at six months and at one year. Subjects were randomly assigned tu ranitidine or sucralfate treatment fur six weeks, and all DU patients received bismuth subsalicylate, metronidazole and tetracycline for the first two weeks. RESULTS: H pylori was eradicated in 66% of patients receiving sucralfate and 92% receiving ranitidine. Compared with healthy volunteers, DU patients demonstrated a 2.7-fold greater basal acid output, a 1.3-fold. greater peakacid output, significantly higher acid output for each dose of pentagastrin and a 1.38-fold increase in the area under the pentagastrin dose acid response curve. Cure of H pylori, irrespective of ulcer healing regimen, resulted in a gradual decrease in acid secretory capacity with basal acid output, peak acid output and area under the pentagastrin dose acid response curvereturning tu healthy volunteer levels by one year. No demonstrable differences were observed in parietal cell sensitivity in all subjects before or after treatment. These data suggest that disturbances in acid secretion in Hpylori-positive DU patients are not due to an increased parietal cell sensitivity to pentagastrin bur rather due to an increased parietal cell mass with increased capacity to secrete acid, which gradually resolves following cure.

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Documento generato il 19/01/20 alle ore 20:13:15