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Titolo:
Preventing diabetes - applying pathophysiological and epidemiological evidence
Autore:
Fujimoto, WY; Bergstrom, RW; Boyko, EJ; Chen, KW; Kahn, SE; Leonetti, DL; McNeely, MJ; Newell, LL; Shofer, JB; Tsunehara, CH; Wahl, PW;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA Univ Washington, Dept Anthropol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Anthropol, Seattle, WA 98195 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA
Titolo Testata:
BRITISH JOURNAL OF NUTRITION
, volume: 84, anno: 2000, supplemento:, 2
pagine: S173 - S176
SICI:
0007-1145(200012)84:<S173:PD-APA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
JAPANESE-AMERICAN MEN; 5-YEAR FOLLOW-UP; GLUCOSE-TOLERANCE; FAT DISTRIBUTION; INSULIN; NIDDM; ASSOCIATION; PREVALENCE; SECRETION; MELLITUS;
Keywords:
beta-cell dysfunction; insulin resistance; metabolic obesity; westernization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Fujimoto, WY Univ Washington, Dept Med, Box 356426, Seattle, WA 98195 USA Univ Washington Box 356426 Seattle WA USA 98195 WA 98195 USA
Citazione:
W.Y. Fujimoto et al., "Preventing diabetes - applying pathophysiological and epidemiological evidence", BR J NUTR, 84, 2000, pp. S173-S176

Abstract

This is a review of research carried out in Japanese Americans that pointstowards possible approaches to prevention of type 2 diabetes mellitus. Thenatural history of type 2 diabetes usually includes both insulin resistance and beta -cell dysfunction. Insulin secretion may compensate for insulin resistance. Alternatively, enhanced insulin sensitivity may mask an insulinsecretory defect. Epidemiological data support the view that in the vast majority of cases of type 2 diabetes, insulin resistance is essential to thepathogenesis of hyperglycemia. Increased diabetes prevalence as ethnic groups migrate to more urban or westernized regions has been attributed to increased occurrence of insulin resistance. Research among Japanese Americans in Seattle, Washington, showed a higher prevalence of type 2 diabetes than in Japan, which suggested that factors associated with 'westernization' might be playing a role in bringing out underlying susceptibility to diabetes. Our research has shown that these impressions were correct and that the abnormalities that characterize the metabolic syndrome play a significant role. Due to increased intra-abdominal fat deposition, Japanese Americans werelikely to be 'metabolically obese' despite relatively normal BMI. A diet higher in animal fat and lower levels of physical activity were risk factorsleading to increased intra-abdominal fat deposition, insulin resistance, and diabetes. information from epidemiological studies such as these may be used to determine whether diabetes may be prevented through changes in lifestyle or application of specific therapies targeted towards identified metabolic abnormalities.

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Documento generato il 05/12/20 alle ore 09:46:18