Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Polyclonal expansion of CD3(+)/CD4(+)/CD56(+) large granular lymphocytes and autoimmunity associated with dysregulation of Fas/FasL apoptotic pathway
Autore:
Camagna, A; Cedrone, L; Care, A; Samoggia, P; De Marco, MC; Del Duca, P; De Martinis, C; Testa, U;
Indirizzi:
Univ La Sapienza, Dept Clin Sci, I-00161 Rome, Italy Univ La Sapienza Rome Italy I-00161 , Dept Clin Sci, I-00161 Rome, Italy Ist Super Sanita, Lab Haematol & Oncol, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 aematol & Oncol, I-00161 Rome, Italy
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 1, volume: 112, anno: 2001,
pagine: 204 - 207
SICI:
0007-1048(200101)112:1<204:PEOCLG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA; LIGAND; PROLIFERATIONS; CD3(+);
Keywords:
apoptosis; autoimmunity; large granular lymphocytes; CD95; polyclonal proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Camagna, A Univ La Sapienza, Dept Clin Sci, Viale Policlin, I-00161 Rome, Italy Univ La Sapienza Viale Policlin Rome Italy I-00161 Rome, Italy
Citazione:
A. Camagna et al., "Polyclonal expansion of CD3(+)/CD4(+)/CD56(+) large granular lymphocytes and autoimmunity associated with dysregulation of Fas/FasL apoptotic pathway", BR J HAEM, 112(1), 2001, pp. 204-207

Abstract

Evidence is accumulating regarding CD95/CD95 ligand (Fas/FasL) pathway dysregulation in clonal diseases of the lymphohaemopoietic lineages. Accordingto these observations, it has been proposed that this defect may representone of the mechanisms of tumour progression. In large granular lymphocyte (LGL) leukaemia, dysregulated apoptosis may represent a key event in the development of malignancy and autoimmunity. This case report describes dysregulation of the Fas/FasL pathway in a chronic polyclonal expansion of CD3(+)LGLs associated with numerous serological immune abnormalities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 19:30:28