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Titolo:
Serotoninergic afferents preferentially innervate distinct subclasses of peptidergic interneurons in the rat visual cortex
Autore:
Paspalas, CD; Papadopoulos, GC;
Indirizzi:
Aristotelian Univ Salonika, Fac Med Vet, Dept Anat & Histol, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006 006 Salonika, Greece
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 891, anno: 2001,
pagine: 158 - 167
SICI:
0006-8993(20010209)891:1-2<158:SAPIDS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; CEREBRAL-CORTEX; MEDIAN RAPHE; NEUROPEPTIDE-Y; DIFFERENTIAL MODULATION; INHIBITORY INTERNEURONS; GABAERGIC INTERNEURONS; SYNAPTIC ORGANIZATION; VOLUME TRANSMISSION; SOMATOSTATIN-LIKE;
Keywords:
serotonin; somatostatin; neuropeptide Y; vasoactive intestinal polypeptide; neuromodulation; cerebral cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Papadopoulos, GC Aristotelian Univ Salonika, Fac Med Vet, Dept Anat & Histol, GR-54006 Salonika, Greece Aristotelian Univ Salonika Salonika Greece GR-54006 ece
Citazione:
C.D. Paspalas e G.C. Papadopoulos, "Serotoninergic afferents preferentially innervate distinct subclasses of peptidergic interneurons in the rat visual cortex", BRAIN RES, 891(1-2), 2001, pp. 158-167

Abstract

Although it is well documented that the non-pyramidal neurons of the cerebral cortex are under the influence of the vast serotoninegic input, the ultrastructural substrate for such functional interactions appears largely obscure. We sought to address this issue by dual immunoelectron microscopy, combining antibodies against serotonin (5-HT) and three neurochemical markersfor peptidergic interneurons. namely somatostatin (SRIF), neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP). The gold-substituted silver-peroxidase method was employed to intensify and differentiate the end-product of the peptide-immunoreaction from the non-intensified 5-HT fibers. Mainly the SRIF but also the NPY neurons were encountered among the postsynaptic targets of the 5-HT boutons. Recipients of synapses were perikarya andproximal dendrites of SRIF and NPY cells but also distal dendrites of the SRIF neurons. Neither synaptic relationships nor close appositions were ever identified between 5-HT boutons and VIP-immunoreactive elements. This remarkable synaptic preference/avoidance of 5-HT afferents for specific peptidergic subpopulations reveals a 'wired' component of cortical serotonin neurotransmission, which should be carefully interpreted within the frame of the available literature for extrasynaptic serotonin release. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:26:27