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Titolo:
Urinary trypsin inhibitor concentration can predict the immunological insult of chemotherapy and complications after bone marrow transplantation
Autore:
Yamada, S; Takatsuka, H; Takemoto, Y; Wada, H; Fujimori, Y; Okamoto, T; Kanamaru, A; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinimiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinimiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Kinki Univ, Sch Med, Dept Internal Med 3, Osaka 589, Japan Kinki Univ Osaka Japan 589 ch Med, Dept Internal Med 3, Osaka 589, Japan
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 2, volume: 27, anno: 2001,
pagine: 195 - 199
SICI:
0268-3369(200101)27:2<195:UTICCP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VERSUS-HOST DISEASE; ELASTASE;
Keywords:
allogeneic bone marrow transplantation; systemic inflammatory response syndrome; urinary trypsin inhibitor; interleukin-6; C-reactive protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Takatsuka, H Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinimiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinimiya Hyogo Japan 6638501
Citazione:
S. Yamada et al., "Urinary trypsin inhibitor concentration can predict the immunological insult of chemotherapy and complications after bone marrow transplantation", BONE MAR TR, 27(2), 2001, pp. 195-199

Abstract

Urinary trypsin inhibitor has attracted attention as an index of the systemic inflammatory response syndrome. In this study, the urine concentration of trypsin inhibitor was measured to compare the immunological insult of conventional chemotherapy and conditioning chemotherapy for bone marrow transplantation. We also investigated whether urinary trypsin inhibitor was a useful index of the complications and outcome of bone marrow transplantation. Urinary trypsin inhibitor concentration was determined before chemotherapy, on the day after finishing chemotherapy (day 0 of transplantation), and during recovery of the white cell count, in 17 patients ( seven receiving conventional chemotherapy and 10 receiving conditioning for bone marrow transplantation). Urinary trypsin inhibitor concentrations were significantly higher after conditioning for bone marrow transplantation than after conventional chemotherapy (P < 0.001), indicating that conditioning was more invasive. After bone marrow transplantation, the incidence of severe complications and the mortality rate were higher in patients whose urinary trypsin inhibitor concentrations rose during recovery of the white cell count. Comparison of urinary trypsin inhibitor concentrations suggested that conditioning for bone marrow transplantation was more invasive than conventional chemotherapy, This study also suggested that the urine concentration of trypsin inhibitor could be useful for predicting the risk of complications and outcome of bone marrow transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:31:03