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Titolo:
Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with geneticiron overload disorders
Autore:
Canonne-Hergaux, F; Levy, JE; Fleming, MD; Montross, LK; Andrews, NC; Gros, P;
Indirizzi:
McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada McGill Univ Montreal PQ Canada H3G 1Y6 chem, Montreal, PQ H3G 1Y6, Canada Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 iv Hematol Oncol, Boston, MA 02115 USA Howard Hughes Med Inst, Boston, MA 02115 USA Howard Hughes Med Inst Boston MA USA 02115 Med Inst, Boston, MA 02115 USA Brigham & Womens Hosp, Div Hematol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 v Hematol, Boston, MA 02115 USA Childrens Hosp, Dept Pathol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pediat, Boston, MA 02115 USA
Titolo Testata:
BLOOD
fascicolo: 4, volume: 97, anno: 2001,
pagine: 1138 - 1140
SICI:
0006-4971(20010215)97:4<1138:EOTD(I>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEREDITARY HEMOCHROMATOSIS; CONGENITAL ATRANSFERRINEMIA; ABSORPTION; TRANSFERRIN; MUTATION; CLONING; ANEMIA; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Gros, P McGill Univ, Dept Biochem, Rm 907,3655 William Osler, Montreal, PQH3G 1Y6, Canada McGill Univ Rm 907,3655 William Osler Montreal PQ Canada H3G 1Y6 a
Citazione:
F. Canonne-Hergaux et al., "Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with geneticiron overload disorders", BLOOD, 97(4), 2001, pp. 1138-1140

Abstract

Iron overload is highly prevalent, but its molecular pathogenesis is poorly understood. Recently, DMT1 was shown to be a major apical iron transporter in absorptive cells of the duodenum, In vivo, it is the only transporter known to be important for the uptake of dietary non-heme iron from the gut lumen. The expression and subcellular localization of DMT1 protein in 3 mouse models of iron over-load were examined: hypotransferrinemic (Trf(hpx)) mice, Hfe knockout mice, and B2m knockout mice. Interestingly, in Trfhpx homozygotes, DMT1 expression was strongly induced in the villus brush border when compared to control animals. This suggests that DMT1 expression is increased in response to iron deficiency in the erythron, even in the setting of systemic iron overload. In contrast, no increase was seen in DMT1 expression in animals with iron overload resembling human hemochromatosis. Therefore, it does not appear that changes in DMT1 levels are primarily responsible for iron loading in hemochromatosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:11:12