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Titolo:
The Kozak sequence polymorphism of platelet glycoprotein Ib alpha and riskof nonfatal myocardial infarction and nonfatal stroke in young women
Autore:
Frank, MB; Reiner, AP; Schwartz, SM; Kumar, PN; Pearce, RM; Arbogast, PG; Longstreth, WT; Rosendaal, FR; Psaty, BM; Siscovick, DS;
Indirizzi:
Univ Washington, Dept Med, Div Hematol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Div Hematol, Seattle, WA 98195 USA Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USAUniv Washington Seattle WA USA 98195 Hlth Res Unit, Seattle, WA 98195 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA PSG Inst Med Sci & Res, Dept Pathol, Coimbatore, Tamil Nadu, India PSG Inst Med Sci & Res Coimbatore Tamil Nadu India re, Tamil Nadu, India Univ Washington, Dept Neurol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Neurol, Seattle, WA 98195 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Univ Leiden Hosp, Dept Clin Epidemiol, NL-2300 RC Leiden, Netherlands UnivLeiden Hosp Leiden Netherlands NL-2300 RC 00 RC Leiden, Netherlands Univ Leiden Hosp, Ctr Hemostasis & Thrombosis Res, NL-2300 RC Leiden, Netherlands Univ Leiden Hosp Leiden Netherlands NL-2300 RC 00 RC Leiden, Netherlands
Titolo Testata:
BLOOD
fascicolo: 4, volume: 97, anno: 2001,
pagine: 875 - 879
SICI:
0006-4971(20010215)97:4<875:TKSPOP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-V-LEIDEN; DISEASE; GENE; ACTIVATION; INCREASES; COMPLEX; HPA-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Reiner, AP Harborview Med Ctr, Box 359756, Seattle, WA 98104 USA Harborview Med Ctr Box 359756 Seattle WA USA 98104 WA 98104 USA
Citazione:
M.B. Frank et al., "The Kozak sequence polymorphism of platelet glycoprotein Ib alpha and riskof nonfatal myocardial infarction and nonfatal stroke in young women", BLOOD, 97(4), 2001, pp. 875-879

Abstract

Several platelet membrane glycoprotein polymorphisms have been identified as potential risk factors for cardiovascular disease. Recently a nucleotide-5T/C dimorphism in the translation initiation site (Kozak sequence) of the platelet glycoprotein Ib alpha (GPIb alpha) gene was associated with increased platelet surface levels of the GPIb-IX-V receptor complex. The role of this GPIb alpha Kozak sequence polymorphism in the occurrence of arterialthrombotic disease is unknown. We performed genotype analysis of the Kozaksequence polymorphism of GPIb alpha in a population-based study of 18- to 44-year-old women with nonfatal myocardial infarction (MI) (n = 78), nonfatal stroke (n = 106), and 384 demographically similar female control subjects. Analysis of -5T/C genotypes revealed that at least one copy of the C allele was present in 14.1% of MI cases, 23.6% of stroke cases, and 23.7% of controls. The age-adjusted odds ratio for MI in women carrying at least one copy of the C allele was 0.53 (95% confidence interval [CI] 0.27-1.05). Theage-adjusted odds ratio for stroke in women carrying at least one copy of the C allele was 0.99 (95% CI 0.59-1.65). Analyses stratified by stroke type (ischemic, hemorrhagic) yielded similar results. In conclusion, young women carrying the C allele of the Kozak sequence polymorphism of GPIb alpha are not at increased risk of MI or stroke. Paradoxically, the C allele may even be associated with a reduced risk of MI in this population. This finding requires further study. (C) 2001 by The American Society of Hematology.

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Documento generato il 27/11/20 alle ore 02:20:03