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Titolo:
Tobacco-smoke-inducible human haem oxygenase-1 gene expression: role of distinct transcription factors and reactive oxygen intermediates
Autore:
Favatier, F; Polla, BS;
Indirizzi:
UFR Cochin Port Royal, Physiol Resp Lab, F-75014 Paris, France UFR Cochin Port Royal Paris France F-75014 sp Lab, F-75014 Paris, France
Titolo Testata:
BIOCHEMICAL JOURNAL
, volume: 353, anno: 2001,
parte:, 3
pagine: 475 - 482
SICI:
0264-6021(20010201)353:<475:THHOGE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-SKIN FIBROBLASTS; SINGLE-STRAND BREAKS; FACTOR KAPPA-B; HEME OXYGENASE; CIGARETTE-SMOKE; OXIDATIVE STRESS; HUMAN MONOCYTES; NUCLEAR FACTOR; LIPID-PEROXIDATION; RESPONSIVE ELEMENT;
Keywords:
binding activity; cadmium-responsive element; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Favatier, F UFR Cochin Port Royal, Physiol Resp Lab, 24 Rue du Faubourg StJacques, F-75014 Paris, France UFR Cochin Port Royal 24 Rue du Faubourg StJacques Paris France F-75014
Citazione:
F. Favatier e B.S. Polla, "Tobacco-smoke-inducible human haem oxygenase-1 gene expression: role of distinct transcription factors and reactive oxygen intermediates", BIOCHEM J, 353, 2001, pp. 475-482

Abstract

Exposure of eukaryotic cells to a variety of reactive-oxygen-intermediate (ROI)-mediated sources of cellular injury, including heavy metals and UV radiation, induces the expression of heat-shock (HS) and stress-related genesamong which is a 32-34 kDa protein identified as inducible haem oxygenase-l (HO-1). We previously showed that tobacco smoke (TS), a potent source of oxidants leading to oxidative stress, induces both HS proteins (HSPs) and HO-1 in normal human monocytes. Here we with consensus elements and binding sites of the promoter region of HO-1[heat-shock factor (HSF), nuclear factor kappaB (NF-kappaB) and activator protein-1 (AP-I)] and the cadmium-responsive element (CdRE) isolated by Takeda, Ishizawa, Sate, Yoshida and Shibahara [(1994) J. Biol. Chem. 269, 22858-22867]. We report an inhibition of NF-kappaB activation by TS, no effect on AP- and a strong activation of CdRE-binding activity, whereas cadmium chelation from TS only partially preventedHO-1 induction. H2O2 also activated the CdRE-binding activity, and pretreatment with N-acetyl-L-cysteine, which replenishes the intracellular levels of GSH, suppressed. in TS-treated cells, both the CdRE-binding activity andthe increased HO-1 expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:56:09