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Titolo:
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
Autore:
Janssens, V; Goris, J;
Indirizzi:
Catholic Univ Louvain, Afdeling Biochem, Fac Geneeskunde, B-3000 Louvain, Belgium Catholic Univ Louvain Louvain Belgium B-3000 de, B-3000 Louvain, Belgium
Titolo Testata:
BIOCHEMICAL JOURNAL
, volume: 353, anno: 2001,
parte:, 3
pagine: 417 - 439
SICI:
0264-6021(20010201)353:<417:PP2AHR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE-T-ANTIGEN; SMALL TUMOR-ANTIGEN; SERINE THREONINE PHOSPHATASES; RABBIT SKELETAL-MUSCLE; XENOPUS-LAEVIS OOCYTES; NF-KAPPA-B; INDUCED GRANULOCYTIC DIFFERENTIATION; ADENOVIRUS E4ORF4 PROTEIN; TERMINAL LEUCINE RESIDUE; MAP KINASE PATHWAY;
Keywords:
cell cycle; dephosphorylation; methylation; PP2A; tumour suppressor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
341
Recensione:
Indirizzi per estratti:
Indirizzo: Goris, J Catholic Univ Louvain, Afdeling Biochem, Fac Geneeskunde, Herestr49, B-3000 Louvain, Belgium Catholic Univ Louvain Herestr 49 Louvain Belgium B-3000 Belgium
Citazione:
V. Janssens e J. Goris, "Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling", BIOCHEM J, 353, 2001, pp. 417-439

Abstract

Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases, minimally containing a well conserved catalytic subunit, the activity of which is highly regulated. Regulation is accomplished mainly by members of a family of regulatory subunits, which determine the substrate specificity. (sub)cellular localization and catalytic activity of the PP2A holoenzymes. Moreover, the catalytic subunit is subject to two types of post-translational modification, phosphorylation and methylation, which are also thought to be important regulatory devices, The regulatory ability of PTPA (PTPase activator), originally identified as a protein stimulating the phosphotyrosine phosphatase activity of PP2A, will also be discussed, alongside the other regulatory inputs. The use of specific PP2A inhibitors and molecular genetics in yeast, Drosophila and mice has revealed roles for PP2A in cell cycle regulation, cell morphology and development, PP2A also plays a prominent role in the regulation of specific signal transduction cascades, as witnessed by its presence in a number of macromolecular signalling modules,where it is often found in association with other phosphatases and kinases. Additionally, PP2A interacts with a substantial number of other cellular and viral proteins. which are PP2A substrates, target PP2A to different subcellular compartments or affect enzyme activity. Finally, the de-regulationof PP2A in some specific pathologies will be touched upon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 00:01:01