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Titolo:
Identification of mu-opioid receptor epitopes recognized by agonistic IgG
Autore:
Mace, G; Jaume, M; Druet, E; Blanpied, C; Nguyen, C; Druet, P; Dietrich, G;
Indirizzi:
Hop Purpan, INSERM U28, F-31059 Toulouse, France Hop Purpan Toulouse France F-31059 INSERM U28, F-31059 Toulouse, France Univ Toulouse 3, Hop Purpan, Inst Claude Preval, F-31059 Toulouse, France Univ Toulouse 3 Toulouse France F-31059 Preval, F-31059 Toulouse, France CNRS UMR 5089, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France CNRSUMR 5089 Toulouse France F-31077 l Struct, F-31077 Toulouse, France
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 4, volume: 280, anno: 2001,
pagine: 1142 - 1147
SICI:
0006-291X(20010202)280:4<1142:IOMRER>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
3RD EXTRACELLULAR LOOPS; MORPHINE-LIKE ACTIVITY; NATURAL HUMAN-IGG; SELECTIVE AGONIST; BINDING; SITE; DAMGO; DISTINGUISHES; RESIDUES; LIGAND;
Keywords:
agonistic antibody; mu-opioid receptor; binding site; G protein coupled receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Dietrich, G Hop Purpan, INSERM U28, Pavillon Lefebvre,Pl Dr Baylac, F-31059 Toulouse, France Hop Purpan Pavillon Lefebvre,Pl Dr Baylac Toulouse France F-31059
Citazione:
G. Mace et al., "Identification of mu-opioid receptor epitopes recognized by agonistic IgG", BIOC BIOP R, 280(4), 2001, pp. 1142-1147

Abstract

We have previously reported the presence of IgG antibodies with a morphine-like activity in the serum of healthy individuals. The agonistic activity of IgG was dependent on their binding to the first and the third extracellular loops of the human mu opioid receptor. In this study me show that IgG antibodies obtained by immunizing rats with peptides corresponding to these two loops exhibited a similar morphine-like activity. Residues corresponding to Y-130, M-132, G(133), T-134 within the first and F-315 within the third extracellular segment were required for antibody binding and conferred toIgG a high mu -opioid selectivity. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:27:58