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Titolo:
Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125
Autore:
Nakamura, T; Yamashita, H; Takahashi, T; Nakamura, S;
Indirizzi:
Hiroshima Univ, Dept Internal Med 3, Sch Med, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 4, volume: 280, anno: 2001,
pagine: 1085 - 1092
SICI:
0006-291X(20010202)280:4<1085:AFPAAT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; A-BETA COMPONENT; PARKINSONS-DISEASE; NEURITE OUTGROWTH; PRECURSOR PROTEIN; ALZHEIMER-DISEASE; LEWY BODIES; MUTANT MICE; KINASE; FAMILY;
Keywords:
alpha-synuclein; Parkinson's disease; Fyn; tyrosine phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Yamashita, H Hiroshima Univ, Dept Internal Med 3, Sch Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348551 1, Japan
Citazione:
T. Nakamura et al., "Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125", BIOC BIOP R, 280(4), 2001, pp. 1085-1092

Abstract

alpha -Synuclein is a presynaptic protein of unknown function that has been implicated in the pathogenesis of several neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. To gain insight into the functions of alpha -synuclein, we sought protein kinases that phosphorylate alpha -synuclein in the central nervous system. In contrast to Lyn, PYK2, FAK, MAPK/ ERK1, SAPK/JNK, and Cdk5, only Fyn could phosphorylate alpha -synuclein. In addition, A30P and A53T mutations did not affect the phosphorylationof alpha -synuclein by Fyn. Mutation analysis revealed that activated Fyn phosphorylates specifically tyrosine residue 125 of alpha -synuclein. The distribution of alpha -synuclein and Fyn expression was similar in various parts of the brain and was colocalized in subcellular structures. Since Fyn regulates various signal transduction pathways in the central nervous system and plays an essential role in the neuronal cell differentiation, survival, and plasticity, results of this paper indicate that phosphorylation of alpha -synuclein might be involved in one of the Fyn-mediated signaling pathways in neuronal cells. (C) 2001 Academic Press

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:08:57