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Titolo:
The relationships between post-prandial lipaemia, endothelial function andoxidative stress in healthy individuals and patients with type 2 diabetes
Autore:
Anderson, RA; Evans, ML; Ellis, GR; Graham, J; Morris, K; Jackson, SK; Lewis, MJ; Rees, A; Frenneaux, MP;
Indirizzi:
Univ Wales Coll Med, Wales Heart Res Inst, Dept Cardiol, Cardiff CF4 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales Univ Wales Coll Med, Wales Heart Res Inst, Dept Med, Cardiff CF4 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales Univ Wales Coll Med, Wales Heart Res Inst, Dept Microbiol, Cardiff CF4 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales Univ Wales Coll Med, Wales Heart Res Inst, Dept Pharmacol, Cardiff CF4 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales Univ Wales Inst, Sch Biomed Studies, Cardiff, S Glam, Wales Univ Wales Inst Cardiff S Glam Wales med Studies, Cardiff, S Glam, Wales Liverpool John Moores Univ, Dept Biochem, Liverpool L3 5UX, Merseyside, England Liverpool John Moores Univ Liverpool Merseyside England L3 5UX e, England
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 154, anno: 2001,
pagine: 475 - 483
SICI:
0021-9150(20010201)154:2<475:TRBPLE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICAL GENERATION; HIGH-FAT MEAL; MYOCARDIAL-INFARCTION; BRACHIAL-ARTERY; HYPERTRIGLYCERIDEMIA; CELLS; ATHEROSCLEROSIS; IMPAIRMENT; SERUM; HEART;
Keywords:
oxidative stress; endothelial dysfunction; post-prandial lipoproteins; triglyceride-rich lipoproteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Anderson, RA Univ Wales Coll Med, Wales Heart Res Inst, Dept Cardiol, Heath Pk, CardiffCF4 4XN, S Glam, Wales Univ Wales Coll Med Heath Pk Cardiff S Glam Wales CF4 4XN les
Citazione:
R.A. Anderson et al., "The relationships between post-prandial lipaemia, endothelial function andoxidative stress in healthy individuals and patients with type 2 diabetes", ATHEROSCLER, 154(2), 2001, pp. 475-483

Abstract

Post-prandial lipaemia (PPL) is a factor in atherogenesis and results in reversible endothelial dysfunction in healthy individuals. Oxidative stress and triglyceride (TG)-rich lipoproteins have been implicated. Type 2 diabetes (NIDDM) results in exaggerated PPL. We attempted to delineate the mechanisms of PPL induced, endothelial dysfunction (EF) and oxidative stress in 12 NIDDM and 12 matched healthy subjects. Subjects underwent a fat tolerancetest, with endothelial function assessed by flow-mediated vasodilatation and oxidative stress measured by venous lipid-derived free radicals ex vivo and lipid peroxidation products over the postprandial phase. Fasting TG, post-prandial hypertriglyceridaemia and the TG enrichment of all lipoproteinswas significantly greater in NIDDM. Post-prandial endothelial function inversely correlated with fasting HDL-C (r = - 0.84, P = 0.0001 in both the control and NIDDM groups. The deterioration in EF in the NIDDM group also correlated with TG enrichment of VLDL and LDL. PPL in both groups also resulted in increased oxidative stress. The increment in free radicals correlated with TG enrichment of VLDL in both groups and was, therefore, greater in NIDDM, Thus, PPL - with the production of TG-enrichment of VLDL - results in endothelial dysfunction by an oxidative stress mechanism in both groups. The magnitude is greater in NIDDM. Fasting HDL-C appears to contribute to theprotection of the endothelium against this phenomenon. Hence, exaggerated PPL associated with reduced HDL-C may be important in the pathogenesis of vascular disease, particularly in NIDDM. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:46:16