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Titolo:
Neuropathological correlates of dysarthria in progressive supranuclear palsy
Autore:
Kluin, KJ; Gilman, S; Foster, NL; Sima, AAF; DAmato, CJ; Bruch, LA; Bluemlein, L; Little, R; Johanns, J;
Indirizzi:
Univ Michigan Hlth Syst, Dept Speech Language Pathol, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst Ann Arbor MI USA 48109 l, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst, Dept Neurol, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst Ann Arbor MI USA 48109 l, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst Ann Arbor MI USA 48109 l, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst, Dept Biostat, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst Ann Arbor MI USA 48109 t, Ann Arbor, MI 48109 USA Wayne State Univ, Dept Pathol, Detroit, MI 48202 USA Wayne State Univ Detroit MI USA 48202 Dept Pathol, Detroit, MI 48202 USA Univ Nebraska, Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA Univ Nebraska Omaha NE USA d Ctr, Dept Pathol & Microbiol, Omaha, NE USA
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 2, volume: 58, anno: 2001,
pagine: 265 - 269
SICI:
0003-9942(200102)58:2<265:NCODIP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RICHARDSON-OLSZEWSKI SYNDROME; PATHOLOGY; CRITERIA; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kluin, KJ Univ Michigan Hlth Syst, Dept Speech Language Pathol, Univ Hosp 1D203, 1500 E Med Ctr, Ann Arbor, MI 48109 USA Univ Michigan Hlth Syst 1500E Med Ctr Ann Arbor MI USA 48109 SA
Citazione:
K.J. Kluin et al., "Neuropathological correlates of dysarthria in progressive supranuclear palsy", ARCH NEUROL, 58(2), 2001, pp. 265-269

Abstract

Background: The dysarthria of progressive supranuclear palsy consists of prominent hypokinetic and spastic components with less prominent ataxic components. Objective: To correlate the types of dysarthria with neuropathological changes in patients with progressive supranuclear palsy. Design and Methods: In 14 patients with progressive supranuclear palsy, wecorrelated the perceptual speech findings with the neuropathological findings. A dysarthria assessment was performed a mean +/- SD of 31 +/- 15 months (range, 10-53 months) before death. The deviant speech dimensions were rated on a scale of 0 (normal) to 3 (severe). The neuropathological examination consisted of semiquantitative analysis of neuronal loss and gliosis by investigators (A.A.F.S., and L.A.B.) blinded to the clinical findings. Correlation and linear regression analysis were used to correlate the severity of the hypokinetic, spastic, and ataxic components with the degree of neuronal loss and gliosis in predetermined anatomical sites. Results: All patients had hypokinetic and spastic dysarthria, and 9 also had ataxic components. The severity of the hypokinetic components was significantly correlated with the degree of neuronal loss and gliosis in the substantia nigra pars compacta (r = 0.61, P = .02) and pars reticulata (r = 0.64, P = .01) but not in the subthalamic nucleus (r = 0.51, P = .07) or the striatum or globus pallidus (/r/ < 0.34, P > .20). The severity of the spastic and ataxic components was not significantly correlated with the neuropathological changes in the frontal cortex (r = 0.20, P = .50) and cerebellum (/r/ < 0.28, P > .33), respectively. Conclusion: The hypokinetic dysarthria of progressive supranuclear palsy may result from degenerative changes in the substantia nigra pars compacta and pars reticulata and not from changes in the striatum or globus pallidus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:30:46