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Titolo:
Progression of dysarthria and dysphagia in postmortem-confirmed Parkinsonian disorders
Autore:
Muller, J; Wenning, GK; Verny, M; McKee, A; Chaudhuri, KR; Jellinger, K; Poewe, W; Litvan, I;
Indirizzi:
NINDS, Cognit Neuropharmacol Unit, Def & Vet Head Injury Program, Henry M Jackson Fdn & Med Branch,NIH, Bethesda, MD 20817 USA NINDS Bethesda MD USA20817 Fdn & Med Branch,NIH, Bethesda, MD 20817 USA Univ Innsbruck Hosp, Dept Neurol, A-6020 Innsbruck, Austria Univ InnsbruckHosp Innsbruck Austria A-6020 , A-6020 Innsbruck, Austria Hop La Pitie Salpetriere, Raymond Escourolle Neuropathol Lab, Paris, France Hop La Pitie Salpetriere Paris France le Neuropathol Lab, Paris, France Vet Adm Med Ctr, Geriatr Res Educ Clin Ctr, Bedford, MA USA Vet Adm Med Ctr Bedford MA USA eriatr Res Educ Clin Ctr, Bedford, MA USA Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ch Med, Dept Neurol, Boston, MA 02118 USA Boston Univ, Sch Med, Dept Pathol, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 ch Med, Dept Pathol, Boston, MA 02118 USA Inst Psychiat, Dept Neurol, London SE5 8AF, England Inst Psychiat LondonEngland SE5 8AF ept Neurol, London SE5 8AF, England Ludwig Boltzmann Inst Clin Neurol, Vienna, Austria Ludwig Boltzmann Inst Clin Neurol Vienna Austria eurol, Vienna, Austria
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 2, volume: 58, anno: 2001,
pagine: 259 - 264
SICI:
0003-9942(200102)58:2<259:PODADI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEWY-BODY-DISEASE; MULTIPLE SYSTEM ATROPHY; CLINICAL-FEATURES; CORTICOBASAL DEGENERATION; SUPRANUCLEAR PALSY; SWALLOWING ABNORMALITIES; INTERNATIONAL WORKSHOP; NATURAL-HISTORY; DEMENTIA; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Litvan, I NINDS, Cognit Neuropharmacol Unit, Def & Vet Head Injury Program, Henry M Jackson Fdn & Med Branch,NIH, Champlain Bldg,6410 Rockledge Dr,Suite 600, Bethesda, MD 20817 USA NINDS Champlain Bldg,6410 Rockledge Dr,Suite 600 Bethesda MD USA 20817
Citazione:
J. Muller et al., "Progression of dysarthria and dysphagia in postmortem-confirmed Parkinsonian disorders", ARCH NEUROL, 58(2), 2001, pp. 259-264

Abstract

Background: Dysarthria and dysphagia are known to occur in parkinsonian syndromes such as Parkinson disease (PD), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Differences in the evolution of these symptomshave not been studied systematically in postmortem-confirmed cases. Objective: To study differences in the evolution of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders. Patients and Methods: Eighty-three pathologically confirmed cases (PD, n =17; MSA, n = 15; DLB, n = 14; PSP, n = 24; and CBD, n = 13) formed the basis for a multicenter clinicopathological study organized by the National Institute of Neurological Disorders and Stroke, Bethesda, Md. Cases with enough clinicopathological documentation for the purpose of the study were selected from research and neuropathological files of 7 medical centers in 4 countries (Austria, France, England, and the United States). Results: Median dysarthria latencies were short in PSP and MSA (24 months each), intermediate in CBD and DLB (40 and 42 months), and long in PD (84 months). Median dysphagia latencies were intermediate in PSP (42 months), DLB (43 months), CBD (64 months), and MSA (67 months), and long in PD (130 months). Dysarthria or dysphagia within 1 year of disease onset was a distinguishing feature for atypical parkinsonian disorders (APDs) (specificity, 100%) but failed to further distinguish among the APDs. Survival time after onset of a complaint of dysphagia was similar in PD, MSA, and PSP (15 to 24 months, P = .7) and latency to a complaint of dysphagia was highly correlated with total survival time (p = 0.88; P < .001) in all disorders. Conclusions: Latency to onset of dysarthria and dysphagia clearly differentiated PD from the APDs, but did not help distinguish different APDs. Survival after onset of dysphagia was similarly poor among all parkinsonian disorders. Evaluation and adequate treatment of patients with PD who complain of dysphagia might prevent or delay complications such as aspiration pneumonia, which in turn may improve quality of life and increase survival time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:54:12