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Titolo:
Ligand-exchange reaction of labile "3+1"Tc-99m(V) complexes with SH group-containing proteins
Autore:
Seifert, S; Gupta, A; Syhre, R; Spies, H; Johannsen, B;
Indirizzi:
Rossendorf Inc, Forschungszentrum Rossendorf EV, Inst Bioanorgan & Radiopharmazeut Chem, D-01314 Dresden, Germany Rossendorf Inc Dresden Germany D-01314 ut Chem, D-01314 Dresden, Germany
Titolo Testata:
APPLIED RADIATION AND ISOTOPES
fascicolo: 4, volume: 54, anno: 2001,
pagine: 637 - 644
SICI:
0969-8043(200104)54:4<637:LROL"C>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
3+1-MIXED-LIGAND TC-99M COMPLEXES; RECEPTOR-BINDING; GLUTATHIONE; THIOL; HEMOGLOBIN; BLOOD; RAT;
Keywords:
labile 3+1 Tc complexes; reaction with proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Seifert, S Rossendorf Inc, Forschungszentrum Rossendorf EV, Inst Bioanorgan & Radiopharmazeut Chem, POB 51 01 19, D-01314 Dresden, Germany RossendorfInc POB 51 01 19 Dresden Germany D-01314 n, Germany
Citazione:
S. Seifert et al., "Ligand-exchange reaction of labile "3+1"Tc-99m(V) complexes with SH group-containing proteins", APPL RAD IS, 54(4), 2001, pp. 637-644

Abstract

The reactivity of labile 3 + 1 mixed-ligand Tc-99m complexes of the type [(TcO)-Tc-99m(SES)(RS)] with SES being a tridentate dithiol ligand and glutathione or dimethyleysteamine as monodentate ligands RSH towards proteins was investigated in vitro and in vivo. It was found that the complexes undergo reversible transchelation reactions with SH group-containing components of blood such as albumin or haemoglobin. High labelling yields were obtainedwhen 3 + 1 complexes with the tridentate SSS ligand were used. The biodistribution of blood proteins labelled by ligand exchange reaction with the [(TcO)-Tc-99m(SSS)] or [(TcO)-Tc-99m(SNMeS)] core was studied and compared with the in vivo distribution of the labile 3 + 1 complexes containing glutathione as monodentate ligand. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 08:12:16