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Titolo:
Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid
Autore:
Ito, O; Omata, K; Ito, S; Hoagland, KM; Roman, RJ;
Indirizzi:
Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hysiol, Milwaukee, WI 53226 USA Tohoku Univ, Grad Sch med, Dept Nephrol Endocrinol & Hypertens, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ns, Sendai, Miyagi 9808574, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 3, volume: 280, anno: 2001,
pagine: R822 - R830
SICI:
0363-6119(200103)280:3<R822:EOCEIO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
THICK ASCENDING LIMB; NA-K-ATPASE; CYTOCHROME-P450 EPOXYGENASE; OMEGA-HYDROXYLASE; PROXIMAL TUBULE; ANGIOTENSIN-II; BLOOD-PRESSURE; NITRIC-OXIDE; RAT-KIDNEY; 20-HETE;
Keywords:
20-hydroxyeicosatetraenoic acid; epoxyeicosatrienoic acids; cytochrome P-450; P-450 reductase; kinins; nitric oxide; angiotensin II; angiotensin-converting enzyme;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Roman, RJ Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
O. Ito et al., "Effects of converting enzyme inhibitors on renal P-450 metabolism of arachidonic acid", AM J P-REG, 280(3), 2001, pp. R822-R830

Abstract

The effects of blockade of the renin-angiotensin system on the renal metabolism of arachidonic acid (AA) were examined. Male Sprague-Dawley rats weretreated with vehicle, captopril (25 mg . kg(-1) . day(-1)), enalapril (10 mg . kg(-1) . day(-1)), or candesartan (1 mg . kg(-1) . day(-1)) for 1 wk. The production of 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) by renal cortical microsomes increased in rats treated with captopril by 59 and 24% and by 90 and 58% in rats treated with enalapril. Captopril and enalapril increased 20-HETE production in the outer medulla by 100 and 143%, respectively. In contrast, blockade of ANG II type 1 receptors with candesartan had no effect on the renal metabolism of AA. Captopril and enalapril increased cytochrome P-450 (CYP450) reductase protein levels in the renal cortex and outer medulla and the expression of CYP450 4A protein in the outer medulla. The effects of captopril on the renal metabolism of AA were prevented by the bradykinin-receptor antagonist, HOE-140, or the nitric oxide (NO) synthase inhibitor, N-G-nitro-L-arginine methyl ester. These results suggest that angiotensin- converting enzyme inhibitors may increase the formation of 20-HETE and EETs secondary to increases in theintrarenal levels of kinins and NO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:37:46