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Titolo:
Coupling interval from slow to tachycardiac pacing decides sustained alternans pattern
Autore:
Suzuki, S; Araki, J; Doi, Y; Fujinaka, W; Minami, H; Iribe, G; Mohri, S; Shimizu, J; Hirakawa, M; Suga, H;
Indirizzi:
Natl Cardiovasc Ctr, Res Inst, Osaka 5658565, Japan Natl Cardiovasc Ctr Osaka Japan 5658565 , Res Inst, Osaka 5658565, Japan Okayama Univ, Sch Med, Dept Physiol 2, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 ept Physiol 2, Okayama 7008558, Japan Okayama Univ, Sch Med, Dept Anesthesiol & Resuscitol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 & Resuscitol, Okayama 7008558, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 280, anno: 2001,
pagine: H1368 - H1375
SICI:
0363-6135(200103)280:3<H1368:CIFSTT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE LEFT-VENTRICLE; PULSUS-ALTERNANS; MECHANICAL ALTERNANS; POSTEXTRASYSTOLIC POTENTIATION; MAMMALIAN MYOCARDIUM; TIME-CONSTANT; RESTITUTION; CONTRACTILITY; HEARTS; MECHANOENERGETICS;
Keywords:
myocardium; contractility; calcium handling; arrhythmias;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Suga, H Natl Cardiovasc Ctr, Res Inst, 5-7-1 Fujishirodai, Osaka 5658565, Japan Natl Cardiovasc Ctr 5-7-1 Fujishirodai Osaka Japan 5658565 Japan
Citazione:
S. Suzuki et al., "Coupling interval from slow to tachycardiac pacing decides sustained alternans pattern", AM J P-HEAR, 280(3), 2001, pp. H1368-H1375

Abstract

We discovered that the coupling beat interval from a slow to a tachycardiac pacing period considerably affected the pattern of the beat-to-beat alternation of the tachycardia-induced sustained contractile alternans. We analyzed the relationship between the coupling interval and the pattern and amplitude of the alternans in the isovolumic left ventricle of canine blood-perfused hearts. The alternans pattern and amplitude varied transiently over the first 30-50 beats and became gradually stable over the first minute in all 12 hearts. We discovered that stable alternans, even under the same tachycardiac pacing, had three different strong-weak beat patterns depending onthe coupling interval. A relatively short coupling interval produced a representative sustained alternans of the strong and weak beats. A relatively long coupling interval produced a similar sustained alternans but in a reversed order of even-and odd-numbered beats counted from the coupling interval. However, sustained alternans disappeared after 1-3 specific coupling intervals. We conclude that ventricular pacing rate does not solely determine the pattern and amplitude of sustained contractile alternans induced by tachycardia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:48:01