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Titolo:
IGF-I differentially regulates Bcl-xL and Bax and confers myocardial protection in the rat heart
Autore:
Yamamura, T; Otani, H; Nakao, Y; Hattori, R; Osako, M; Imamura, H;
Indirizzi:
Kansai Med Univ, Dept Thorac & Cardiovasc Surg, Moriguchi, Osaka 570, Japan Kansai Med Univ Moriguchi Osaka Japan 570 rg, Moriguchi, Osaka 570, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 280, anno: 2001,
pagine: H1191 - H1200
SICI:
0363-6135(200103)280:3<H1191:IDRBAB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-I; PERMEABILITY TRANSITION PORE; CYTOCHROME-C; CELL-DEATH; ISOLATED-MITOCHONDRIA; REPERFUSION INJURY; INDUCED APOPTOSIS; MUSCLE-CELLS; RELEASE; BCL-X(L);
Keywords:
insulin-like growth factor-I; Bcl-2 family proteins; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Otani, H Kansai Med Univ, Dept Thorac & Cardiovasc Surg, 10-15 Fumizono Cho, Moriguchi, Osaka 570, Japan Kansai Med Univ 10-15 Fumizono Cho MoriguchiOsaka Japan 570 apan
Citazione:
T. Yamamura et al., "IGF-I differentially regulates Bcl-xL and Bax and confers myocardial protection in the rat heart", AM J P-HEAR, 280(3), 2001, pp. H1191-H1200

Abstract

Bcl-2 family proteins play a crucial role in the cytoprotective action of insulin-like growth factor-I (IGF-I) by regulating cell death signaling at the mitochondrial level. The present study examined the effect of IGF-I on the expression of Bcl-2 family proteins in the rat heart mitochondria in relation to myocardial protection against ischemia-reperfusion injury. Systemic IGF-I (1 mg) treatment in the rat increased Bcl-xL and attenuated Bax 12-24 h later in the heart mitochondria fraction. Permeability transition andcytochrome c release occurred in a Ca2+ concentration-dependent manner in the vehicle-treated mitochondria. This was significantly inhibited by the IGF-I-pretreatment. Moreover, ATP synthesis was significantly greater in theIGF-I-pretreated mitochondria. IGF-I pretreatment 24 h before 25 min of global ischemia in the isolated rat heart model significantly improved recovery of isovolumic left ventricular function and inhibited creatine kinase release during reperfusion. This was associated with a significantly less number of terminal transferase labeling-positive myocytes and nonmyocytes 2 h after reperfusion. These results suggest that IGF-1 differentially regulates Bcl-xL and Bax in heart mitochondria, which may be causally related to myocardial protection against ischemia-reperfusion injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:55:11