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Titolo:
Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases
Autore:
Hussain, MB; MacAllister, RJ; Hobbs, AJ;
Indirizzi:
Univ Coll London, Wolfson Inst Biomed Res, London WC1E 6AE, England Univ Coll London London England WC1E 6AE d Res, London WC1E 6AE, England Univ Coll London, Rayne Inst, Ctr Clin Pharmacol, London WC1E 6JJ, EnglandUniv Coll London London England WC1E 6JJ macol, London WC1E 6JJ, England
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 280, anno: 2001,
pagine: H1151 - H1159
SICI:
0363-6135(200103)280:3<H1151:RROCVB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; VASCULAR SMOOTH-MUSCLE; NITRIC-OXIDE SYNTHASE; ENDOTHELIUM-INDEPENDENT RELAXATION; CYCLIC-GMP; GLYCERYL TRINITRATE; CROSS-TOLERANCE; BLOOD-PRESSURE; CELLS; DESENSITIZATION;
Keywords:
soluble guanylate cyclase; particulate guanylate cyclase; nitric oxide; atrial natriuretic peptide; guanosine cyclic 3 ' 5 '-monophosphate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Hobbs, AJ Univ Coll London, Wolfson Inst Biomed Res, Cruciform Bldg,Gower St, LondonWC1E 6AE, England Univ Coll London Cruciform Bldg,Gower St London England WC1E 6AE
Citazione:
M.B. Hussain et al., "Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases", AM J P-HEAR, 280(3), 2001, pp. H1151-H1159

Abstract

Nitric oxide (NO) and atrial natriuretic peptides (ANP) activate soluble (sGC) and particulate guanylate cyclase (pGC), respectively, and play important roles in the maintenance of cardiovascular homeostasis. However, littleis known about potential interactions between these two cGMP-generating pathways. Here we demonstrate that sGC and pGC cooperatively regulate cGMP-mediated relaxation in human and murine vascular tissue. In human vessels, the potency of spermine-NONOate (SPER-NO) and ANP was increased after inhibition of endogenous NO synthesis and decreased by prior exposure to glyceryl trinitrate (GTN). Aortas from endothelial NO synthase (eNOS) knockout (KO) mice were more sensitive to ANP than tissues from wild-type (WT) animals. However, in aortas from WT mice, the potency of ANP was increased after pretreatment with NOS or sGC inhibitor. Vessels from eNOS KO animals were less sensitive to ANP after GTN pretreatment, an effect that was reversed in thepresence of an sGC inhibitor. cGMP production in response to SPER-NO and ANP was significantly greater in vessels from eNOS KO animals compared with WT animals. This cooperative interaction between NO and ANP may have important implications for human pathophysiologies involving deficiency in eithermediator and the clinical use of nitrovasodilators.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:09:09