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Titolo:
20-HETE modulates myogenic response of skeletal muscle resistance arteriesfrom hypertensive Dahl-SS rats
Autore:
Frisbee, JC; Roman, RJ; Krishna, UM; Falck, JR; Lombard, JH;
Indirizzi:
Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hysiol, Milwaukee, WI 53226 USA Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 ed Ctr, Dept Biochem, Dallas, TX 75390 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 3, volume: 280, anno: 2001,
pagine: H1066 - H1074
SICI:
0363-6135(200103)280:3<H1066:2MMROS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL ARCUATE ARTERIES; ARACHIDONIC-ACID; VASCULAR TONE; 20-HYDROXYEICOSATETRAENOIC ACID; CEREBRAL-ARTERIES; SMOOTH-MUSCLE; NITRIC-OXIDE; CYTOCHROME-P-450; ENDOTHELIUM; ACTIVATION;
Keywords:
cytochrome P-450 4A enzymes; cytochrome P-450 omega-hydroxylase; potassium channels; vascular smooth muscle; dibromododecynyl-methylsulfimide; 17-octadecynoic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lombard, JH Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
J.C. Frisbee et al., "20-HETE modulates myogenic response of skeletal muscle resistance arteriesfrom hypertensive Dahl-SS rats", AM J P-HEAR, 280(3), 2001, pp. H1066-H1074

Abstract

The present study determined the role of 20-hydroxyeicosatetraenoic acid [20-HETE; produced by omega -hydroxylation of arachidonic acid via cytochrome P-450 (CP450) 4A enzymes] in regulating myogenic activation of skeletal muscle resistance arteries from normotensive (NT) and hypertensive (HT) Dahlsalt-sensitive (SS) rats. Gracilis arteries (GA) were isolated from each rat and viewed via television microscopy, and changes in vessel diameter with altered transmural pressure were measured with a video micrometer. Under control conditions, GA from both groups exhibited strong, endothelium-independent myogenic activation. Treatment of GA with 17-octadecynoic acid (17-ODYA; inhibitor of CP450 4A enzymes) did not alter myogenic activation in NTrats, but impaired this response in HT animals. Treatment of GA from HT rats with dibromo-dodecynyl-methylsulfimide (DDMS; inhibitor of 20-HETE production) impaired myogenic activation, as did application of 20-hydroxyeicosa-6(Z), 15(Z)-dienoic acid, an antagonist for 20-HETE receptors. Applicationof iberiotoxin, a Ca2+-activated potassium (K-Ca) channel inhibitor, restored myogenic activation from HT rats treated with DDMS. These results suggest that myogenic activation of skeletal muscle resistance arteries from NT Dahl-SS rats does not depend on CP450, whereas myogenic activation of thesevessels in HT Dahl-SS rats is partly a function of 20-HETE production, inhibiting K-Ca channels through a receptor-mediated process.

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Documento generato il 29/03/20 alle ore 08:30:16