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Titolo:
Generation of growth hormone pulsatility in women: evidence against somatostatin withdrawal as pulse initiator
Autore:
Dimaraki, EV; Jaffe, CA; Demott-Friberg, R; Russell-Aulet, M; Bowers, CY; Marbach, P; Barkan, AL;
Indirizzi:
Univ Michigan, Dept Internal Med, Div Endocrinol & Metab, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 nol & Metab, Ann Arbor, MI 48109 USA Vet Affairs Med Ctr, Ann Arbor, MI 48109 USA Vet Affairs Med Ctr Ann Arbor MI USA 48109 d Ctr, Ann Arbor, MI 48109 USA Tulane Univ, Dept Internal Med, Div Endocrinol & Metab, New Orleans, LA 70112 USA Tulane Univ New Orleans LA USA 70112 l & Metab, New Orleans, LA 70112 USA Novartis Pharma Ltd, CH-4002 Basel, Switzerland Novartis Pharma Ltd Basel Switzerland CH-4002 CH-4002 Basel, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 3, volume: 280, anno: 2001,
pagine: E489 - E495
SICI:
0193-1849(200103)280:3<E489:GOGHPI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GH-RELEASING HORMONE; THYROID-STIMULATING HORMONE; (GH)-RELEASING FACTOR; ENDOGENOUS SOMATOSTATIN; SECRETION; ANALOG; SHEEP; RAT; INVOLVEMENT; INFUSION;
Keywords:
growth hormone-releasing peptide; humans; pituitary; hypothalamic control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Barkan, AL 3920 Taubman Ctr,Box 0354, Ann Arbor, MI 48109 USA 3920 Taubman Ctr,Box 0354 Ann Arbor MI USA 48109 MI 48109 USA
Citazione:
E.V. Dimaraki et al., "Generation of growth hormone pulsatility in women: evidence against somatostatin withdrawal as pulse initiator", AM J P-ENDO, 280(3), 2001, pp. E489-E495

Abstract

To test whether endogenous hypothalamic somatostatin (SRIH) fluctuations are playing a role in the generation of growth hormone (GH) pulses, continuous subcutaneous octreotide infusion (16 mug/h) was used to create constant supraphysiological somatostatinergic tone. Six healthy postmenopausal women(age 67 +/- 3 yr, body mass index 24.7 +/- 1.2 kg/m(2)) were studied during normal saline and octreotide infusion providing stable plasma octreotide levels of 2,567 +/- 37 pg/ml. Blood samples were obtained every 10 min for 24 h, and plasma GH was measured with a sensitive chemiluminometric assay. Octreotide infusion suppressed 24-h mean GH by 84 +/- 3% (P = 0.00026), GH pulse amplitude by 90 +/- 3% (P = 0.00031), and trough GH by 54 +/- 5% (P =0.0012), whereas GH pulse frequency remained unchanged. The response of GHto GH-releasing hormone (GHRH) was not suppressed, and the GH response to GH-releasing peptide-6 (GHRP-6) was unaffected. We conclude that, in women,periodic declines in hypothalamic SRIH secretion are not the driving forceof endogenous GH pulses, which are most likely due to episodic release of GHRH and/or the endogenous GHRP-like ligand.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 05:09:18