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Titolo:
Tryptophan glycoconjugate as a novel marker of renal function
Autore:
Takahira, R; Yonemura, K; Yonekawa, O; Iwahara, K; Kanno, T; Fujise, Y; Hishida, A;
Indirizzi:
Hamamatsu Univ, Sch Med, Hemodialysis Unit, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Univ, Sch Med, Dept Med, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Univ, Sch Med, Dept Lab Med, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Univ, Sch Med, Dept Chem, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Seirei Hamamatsu Gen Hosp, Hamamatsu, Shizuoka, Japan Seirei Hamamatsu GenHosp Hamamatsu Shizuoka Japan atsu, Shizuoka, Japan
Titolo Testata:
AMERICAN JOURNAL OF MEDICINE
fascicolo: 3, volume: 110, anno: 2001,
pagine: 192 - 197
SICI:
0002-9343(20010215)110:3<192:TGAANM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREATININE MEASUREMENTS; FILTRATION MARKER; HUMAN URINE; PROGRESSION; FAILURE; INSUFFICIENCY; CIMETIDINE; RESERVE; MASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Yonemura, K Hamamatsu Univ, Sch Med, Hemodialysis Unit, 3600 Handa Cho, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ 3600 Handa Cho Hamamatsu Shizuoka Japan 4313192
Citazione:
R. Takahira et al., "Tryptophan glycoconjugate as a novel marker of renal function", AM J MED, 110(3), 2001, pp. 192-197

Abstract

PURPOSE: Neither serum creatinine concentration nor creatinine clearance assess renal function accurately. Serum creatinine concentration is affectedby muscle mass, and the creatinine clearance overestimates the glomerular filtration rate because of tubular secretion of creatinine. The present study was designed to determine whether serum concentrations of 2-(alpha -mannopyranosyl)-L-tryptoyhan (MPT), a tryptophan glyco-conjugate, can be used as a marker of renal function. METHODS: Clearances of MPT and of inulin were compared in normal rats and in rats with cisplatin-induced acute renal failure. We also compared the clearances of MPT and of creatinine with inulin clearance in 25 patients withchronic renal disease. Serum concentrations of MPT and creatinine as a function of MPT clearance were determined in 108 patients with chronic renal disease. RESULTS: There was strong linear correlation between clearances of MPT andinulin in rats (r = 0.97) and humans (r = 0.87), indicating that renal handling of MPT is similar to that of inulin. In humans, linear regression analyses indicated that MPT was a better indicator of inulin clearance than was creatinine clearance. At the same level of renal function, serum creatinine concentrations tended to be lower in patients with less muscle mass las indicated by a urinary creatinine excretion <1,000 mg in 24 hours) than in those who excreted > 1,000 mg in 24 hours, whereas serum MPT concentrationswere not affected by creatinine excretion. CONCLUSION: MPT clearance can replace inulin clearance in the clinical setting. The serum MPT concentration is an accurate measure of renal function even in patients with diminished muscle mass, and thus is a better indicator of renal function than is the serum creatinine concentration. (C)2001 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:57:12